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Umeå universitet
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Personalbild Karin Forsberg
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Karin Forsberg

Forskningsområde med fokus på neurodegenerativa sjukdomar och särskilt ALS.

Kontakt

E-post
karin.forsberg@umu.se
Telefon
090-785 10 19

Verksam som

Anknytning
Universitetslektor, specialistutbildad läkare vid Institutionen för klinisk vetenskap Enhet: Neurovetenskaper
Plats
Norrlands universitetssjukhus, Umeå universitet, Klinisk vetenskap Umeå universitet, Klinisk vetenskap, 901 85 Umeå
Anknytning
Läkare vid Institutionen för medicinsk biovetenskap Enhet: Patologi
Plats
By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

Mitt forskningsområde är neurodegenerativa sjukdomar och särskilt sjukdomen amyotrofisk lateralskleros (ALS). I min forskning undersöker jag samband mellan kliniska sjukdomsuttryck av ALS, genetiska varianter och hur det ser ut mikroskopiskt i hjärnan. Målet är att hitta nya angreppspunkter för behandling. Jag är också neurolog och prövare i kliniska läkemedelsstudier med syfte att bromsa och förebygga ALS.

Alzheimer's disease traits in Parkinson's disease without α-synuclein seeding
Alzheimer's & Dementia: Journal of the Alzheimer's Association, John Wiley & Sons 2025, Vol. 21, (5)
Fernandes Gomes, Bárbara; Farris, Carly M.; Ma, Yihua; et al.
A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease
Alzheimer's & Dementia: Journal of the Alzheimer's Association, John Wiley & Sons 2025, Vol. 21, (4)
Janelidze, Shorena; Ashton, Nicholas J.; Orduña Dolado, Anna; et al.
SOD1 protein content in human central nervous system and peripheral tissues
Journal of Neurochemistry, John Wiley & Sons 2025, Vol. 169, (6)
Leykam, Laura; Jonsson, Andreas P.; Forsberg, Karin M. E.; et al.
Pathology of three ALS patients with FUS variants, including one likely benign Q23L variant lacking FUS inclusions
Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (18) : 1553-1562
Stenvall, Erica; Åman Grönlund, Kornelia; Rohan, Zdenek; et al.
10-year mortality, causes of death and cardiovascular comorbidities in idiopathic normal pressure hydrocephalus
Journal of Neurology, Springer Nature 2024, Vol. 271 : 1311-1319
Eklund, Sanna; Israelsson, Hanna; Brunström, Mattias; et al.
Precisionsmedicinsk genterapi har bromsat utveckling av ALS: [SOD1 gene therapy delays ALS disease progression]
Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121
Forsberg, Karin; Karlsborg, Merete; Salvesen, Lisette; et al.
Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations
Neurobiology of Disease, Elsevier 2024, Vol. 202
Leykam, Laura; Forsberg, Karin; Nordström, Ulrika; et al.
Small striatal huntingtin inclusions in patients with motor neuron disease with reduced penetrance and intermediate HTT gene expansions
Human Molecular Genetics, Oxford University Press 2024, Vol. 33, (22) : 1966-1974
Roos, Anna-Karin; Stenvall, Erica; Kockum, Emmy Skelton; et al.
Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriers
EBioMedicine, Elsevier 2023, Vol. 90
Dorst, Johannes; Weydt, Patrick; Brenner, David; et al.
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.
Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
European Journal of Neurology, John Wiley & Sons 2022, Vol. 29, (4) : 1279-1283
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; et al.
De novo mutations in SOD1 are a cause of ALS
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2022, Vol. 93 : 201-206
Müller, Kathrin; Oh, Ki-Wook; Nordin, Angelica; et al.
Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Behzadi, Arvin; Pujol-Calderón, Fani; Tjust, Anton E.; et al.
ALS kan vara en prionsjukdom: Inklusioner av felvecklat SOD1-protein tycks finnas hos patienter med alla typer av ALS
Läkartidningen, Läkartidningen Förlag AB 2020, Vol. 117
Forsberg, Karin; Tjust, Anton E.; Zetterström, Per; et al.
Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis
Neurology: Neuroimmunology & Neuroinflammation, Wolters Kluwer 2020, Vol. 7, (3)
Olesen, Mads Nikolaj; Wuolikainen, Anna; Nilsson, Anna Christine; et al.
Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis
Science immunology, American Association for the Advancement of Science 2020, Vol. 5, (53)
Pröbstel, Anne-Katrin; Zhou, Xiaoyuan; Baumann, Ryan; et al.
Histological correlates of postmortem ultra-high-resolution single-section MRI in cortical cerebral microinfarcts
Acta neuropathologica communications, Springer Nature 2020, Vol. 8
Yilmazer-Hanke, Deniz; Mayer, Theresa; Mueller, Hans-Peter; et al.
Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2019, Vol. 90, (8) : 861-869
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Pakkenberg, Bente; et al.
Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis
Acta Neuropathologica, Springer 2018, Vol. 136, (6) : 939-953
Ekhtiari Bidhendi, Elaheh; Bergh, Johan; Zetterström, Per; et al.
Endothelial damage, vascular bagging and remodeling of the microvascular bed in human microangiopathy with deep white matter lesions
Acta neuropathologica communications, BioMed Central 2018, Vol. 6
Forsberg, Karin; Zhang, Yingshuang; Reiners, Johanna; et al.
Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 18, (3-4) : 256-264
Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna; et al.
Extensive size variability of the GGGGCC expansion in C9orf72 in both neuronal and non-neuronal tissues in 18 patients with ALS or FTD
Human Molecular Genetics, Vol. 24, (11) : 3133-3142
Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna; et al.
Improved survival in myeloma patients: starting to close in on the gap between elderly patients and a matched normal population
British Journal of Haematology, Wiley-Blackwell 2014, Vol. 164, (5) : 684-693
Liwing, Johan; Uttervall, Katarina; Lund, Johan; et al.
THE REVII TRIAL: LENALIDOMIDE AND DEXAMETHASONE AS SECOND LINE TREATMENT IN MYELOMA FOLLOWED BY EXTENDED LENALIDOMID VS LEN/DEX
Haematologica, Vol. 99 (Suppl 1), (P352) : 104-105
Lund, J.; Gruber, A.; Lauri, B.; et al.
Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis
Human Molecular Genetics, Vol. 22, (1) : 51-60
Graffmo, Karin S.; Forsberg, Karin; Bergh, Johan; et al.
Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial
Blood, Vol. 121, (23) : 4647-4654
Mellqvist, Ulf-Henrik; Gimsing, Peter; Hjertner, Oyvind; et al.
Is Multiple Myeloma a Chronic Disease?: A Population Based Study Comparing 1843 Patients to a Matched Swedish Population
Blood, American Society of Hematology 2012, Vol. 120, (21)
Nahi, Hareth; Liwing, Johan; Aldrin, Anders; et al.
Misfolded superoxide dismutase-1 in sporadic and familial Amyotrophic Lateral Sclerosis
Umeå University medical dissertations, 1438
Forsberg, Karin
Felveckat protein funnet vid alla former av ALS
Läkartidningen, Sveriges läkarförbund 2011, Vol. 108, (49) : 2560-2560
Forsberg, Karin
Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis
Acta Neuropathologica, SpringerLink 2011, Vol. 121, (5) : 623-634
Forsberg, Karin; Andersen, Peter M; Marklund, Stefan L; et al.
Superoxide dismutase-1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice
Journal of Neurochemistry, Vol. 114, (2) : 408-418
Bergemalm, Daniel; Forsberg, Karin; Srivastava, Vaibhav; et al.
Novel antibodies reveal inclusions containing non-native SOD1 in sporadic ALS patients
PLOS ONE, Public library of science 2010, Vol. 5, (7) : e11552-
Forsberg, Karin; Jonsson, P Andreas; Andersen, Peter M; et al.
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
Blood, Vol. 116, (9) : 1405-1412
Waage, Anders; Gimsing, Peter; Fayers, Peter; et al.
Combined analysis of neurofilament light chain and interleukin 6 in plasma reveals distinct molecular phenotypes in ALS and can differentiate ALS patients into prognostic subgroups
Behzadi, Arvin; Olesen, Mads Nikolaj; Pujol-Calderón, Fani; et al.
Cardiac troponin T, cystatin C and creatine kinase as biomarkers in clinical phenotypes, genotypes and prognostication in amyotrophic lateral sclerosis
Behzadi, Arvin; Wuolikainen, Anna; Tjust, Anton E.; et al.
High expression of wild-type human superoxide dismutase-1 gives a model of sporadic ALS
Forsberg, Karin; Graffmo, Karin S; Zetterström, Per; et al.
ALS patients with the SOD1 D90A mutation show both spinal cord and frontal cortical pathology
Graffmo, Karin S; Forsberg, Karin; Marklund, Stefan L; et al.
Visa publikationer i DiVA