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Umeå universitet
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Personalbild Ulf Ahlgren

Ulf Ahlgren

Jag forskar inom området molekylär medicin. Mitt specialområde är avbildningsteknologier för att studera diabetes.

Vetenskaplig meritering: Docent
0000-0001-5923-8572

Kontakt

E-post
ulf.ahlgren@umu.se
Telefon
090-786 50 55

Verksam som

Anknytning
Professor vid Institutionen för medicinsk och translationell biologi Enhet: Avdelningen för molekylär medicin
Plats
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå
Illuminating the pancreas: a new view on islet cellularity and β-cell distribution in health and disease
European Islet Study Group 2025: conference program, Lund University Diabetes Centre 2025 : 22-22
Ahlgren, Ulf
Influence of the pre-membrane and envelope proteins on structure, pathogenicity, and tropism of tick-borne encephalitis virus
Journal of Virology, American Society for Microbiology 2025, Vol. 99, (9)
Rosendal, Ebba; Bisikalo, Kyrylo; Willekens, Stefanie M. A.; et al.
Development of the pancreas
Kaufman's atlas of mouse development supplement: with coronal sections, Academic Press 2024 : 289-321
Davies, Wayne I. L.; Hörnblad, Andreas; Hahn, Max; et al.
SARS-CoV-2 infection induces hyaluronan production in vitro and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study
mBio, American Society for Microbiology 2024, Vol. 15, (10)
Hellman, Urban; Rosendal, Ebba; Lehrstrand, Joakim; et al.
Illuminating the complete ß-cell mass of the human pancreas - signifying a new view on the islets of Langerhans
Nature Communications, Springer Nature 2024, Vol. 15, (1)
Lehrstrand, Joakim; Davies, Wayne I. L.; Hahn, Max; et al.
An MR-based brain template and atlas for optical projection tomography and light sheet fluorescence microscopy in neuroscience
Frontiers in Neuroscience, Frontiers Media S.A. 2024, Vol. 18
Willekens, Stefanie M. A.; Morini, Federico; Mediavilla, Tomás; et al.
Type I interferon shapes brain distribution and tropism of tick-borne flavivirus
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Chotiwan, Nunya; Rosendal, Ebba; Willekens, Stefanie M. A.; et al.
3D optical molecular imaging of the rodent pancreas by OPT and LSFM
Type-1 diabetes: methods and protocols, New York: Humana Press 2023 : 1-19
Hahn, Max; Ahlgren, Ulf
Quantitative 3D OPT and LSFM datasets of pancreata from mice with streptozotocin-induced diabetes
Scientific Data, Nature Publishing Group 2022, Vol. 9
Hahn, Max; Nord, Christoffer; van Krieken, Pim P.; et al.
Mesoscopic Optical Imaging of the Pancreas: Revisiting Pancreatic Anatomy and Pathophysiology
Frontiers in Endocrinology, Frontiers Media S.A. 2021, Vol. 12
Alanentalo, Tomas; Hahn, Max; Willekens, Stefanie M. A.; et al.
Distinct opsin 3 (Opn3) expression in the developing nervous system during mammalian embryogenesis
eNeuro, Society for Neuroscience 2021, Vol. 8, (5)
Davies, Wayne I. L.; Sghari, Soufien; Upton, Brian A.; et al.
Insulin-Binding Peptide Probes Provide a Novel Strategy for Pancreatic β-Cell Imaging
Molecular Pharmaceutics, American Chemical Society (ACS) 2021, Vol. 18, (12) : 4428-4436
Eriksson, Maria; Litwak, Sara A.; Yun, Yan; et al.
3D imaging of human organs with micrometer resolution - applied to the endocrine pancreas
Communications Biology, Springer Nature 2021, Vol. 4, (1)
Hahn, Max; Nord, Christoffer; Eriksson, Maria; et al.
Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease
Journal of Pathology, John Wiley & Sons 2021, Vol. 254, (1) : 31-45
Quilichini, Evans; Fabre, Mélanie; Nord, Christoffer; et al.
Gsα-dependent signaling is required for postnatal establishment of a functional β-cell mass
Molecular Metabolism, Elsevier 2021, Vol. 53
Serra-Navarro, Berta; Fernandez-Ruiz, Rebeca; García-Alamán, Ainhoa; et al.
Novel Strategies to Protect and Visualize Pancreatic beta Cells in Diabetes
Trends in endocrinology and metabolism, Elsevier 2020, Vol. 31, (12) : 905-917
Gurzov, Esteban N.; Ke, Pu Chun; Ahlgren, Ulf; et al.
Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence
Scientific Reports, Springer Nature 2020, Vol. 10, (1)
Hahn, Max; Nord, Christoffer; Franklin, Oskar; et al.
Topologically selective islet vulnerability and self-sustained downregulation of markers for β-cell maturity in streptozotocin-induced diabetes
Communications Biology, Nature Publishing Group 2020, Vol. 3, (1)
Hahn, Max; van Krieken, Pim P.; Nord, Christoffer; et al.
The effect of hypergastrinemia following sleeve gastrectomy and pantoprazole on type 2 diabetes mellitus and beta-cell mass in Goto-Kakizaki rats
Journal of Endocrinological Investigation, Springer 2018, Vol. 41, (6) : 691-701
Grong, E.; Nord, Christoffer; Arbo, I. B.; et al.
Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats
Diabetologia, Springer 2018, Vol. 61, (4) : 896-905
Medina, Anya; Parween, Saba; Ullsten, Sara; et al.
Biochemical profiling of diabetes disease progression by multivariate vibrational microspectroscopy of the pancreas
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Nord, Christoffer; Eriksson, Maria; Dicker, Andrea; et al.
Spatial and quantitative datasets of the pancreatic beta-cell mass distribution in lean and obese mice
Scientific Data, Vol. 4
Parween, Saba; Eriksson, Maria; Nord, Christoffer; et al.
Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes
Scientific Reports, NATURE PUBLISHING GROUP 2017, Vol. 7
van Krieken, Pim P.; Dicker, Andrea; Eriksson, Maria; et al.
SPECT-OPT multimodal imaging enables accurate evaluation of radiotracers for beta-cell mass assessments
Scientific Reports, Vol. 6
Eter, Wael A.; Parween, Saba; Joosten, Lieke; et al.
Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography
Surgical Endoscopy, Vol. 30, (2) : 532-542
Grong, Eivind; Kulseng, Bård; Arbo, Ingerid Brænne; et al.
Intra-islet lesions and lobular variations in β-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Parween, Saba; Kostromina, Elena; Nord, Christoffer; et al.
The pancreas
Kaufman's atlas of mouse development supplement: with coronal sections, Elsevier 2015 : 85-94
Hörnblad, Andreas; Nord, Christoffer; Parween, Saba; et al.
Light scattering as an intrinsic indicator for pancreatic islet cell mass and secretion
Scientific Reports, Vol. 5
Ilegems, E.; van Krieken, P. P.; Edlund, P. K.; et al.
A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development
Disease Models and Mechanisms, Vol. 8, (12) : 1517-1529
Jones, Iwan; Hägglund, Anna-Carin; Törnqvist, Gunilla; et al.
Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism
PLOS ONE, Vol. 10, (5)
Witek, Barbara; El Wakil, Abeer; Nord, Christoffer; et al.
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
Nature Biotechnology, Vol. 32, (1) : 76-83
Baeyens, Luc; Lemper, Marie; Leuckx, Gunter; et al.
Differential regulation of myosin heavy chains defines new muscle domains in zebrafish
Molecular Biology of the Cell, American Society for Cell Biology 2014, Vol. 25, (8) : 1384-1395
Nord, Hanna; Burguiere, Anne-Cecile; Muck, Joscha; et al.
Imaging shows insulin-producing cells in diabetes
TrAC. Trends in analytical chemistry, Vol. 44 : III-III
Ahlgren, Ulf
Improving signal detection in emission optical projection tomography via single source multi-exposure image fusion
Optics Express, Optical Society of America 2013, Vol. 21, (14) : 16584-16604
Cheddad, Abbas; Nord, Christoffer; Hörnblad, Andreas; et al.
Near infrared optical projection tomography for assessments of beta-cell mass distribution in diabetes research
Journal of Visualized Experiments, Vol. 71
Eriksson, Anna U.; Svensson, Christoffer; Hörnblad, Andreas; et al.
The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model
Physical Biology, Institute of Physics Publishing (IOPP) 2013, Vol. 10, (3) : 036009-
Jo, Junghyo; Hörnblad, Andreas; Kilimnik, German; et al.
Neurogenin 3(+) cells contribute to beta-cell neogenesis and proliferation in injured adult mouse pancreas
Cell Death and Disease, London: Nature Publishing Group 2013, Vol. 4 : e523-
Van de Casteele, M.; Leuckx, G.; Baeyens, L.; et al.
Exploring the pancreas with optical projection tomography
Imaging in Medicine, Vol. 4, (1) : 5-7
Ahlgren, Ulf
Image processing assisted algorithms for optical projection tomography
IEEE Transactions on Medical Imaging, Vol. 31, (1) : 1-15
Cheddad, Abbas; Svensson, Christoffer; Sharpe, James; et al.
Mathematical models of pancreatic islet size distributions
Islets, Landes bioscience 2012, Vol. 4, (1) : 10-19
Jo, Junghyo; Hara, Manami; Ahlgren, Ulf; et al.
The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.
Diabetologia, Vol. 55, (12) : 3331-40
Pardo, F N; Altirriba, J; Pradas-Juni, M; et al.
Imaging the pancreatic beta cell: chapter 13
Type 1 diabetes: pathogenesis, genetics and immunotherapy
Ahlgren, Ulf; Kostromina, Elena
An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution
Islets, Austin: Landes Bioscience 2011, Vol. 3, (4) : 204-208
Hörnblad, Andreas; Cheddad, Abbas; Ahlgren, Ulf
Impaired spleen formation perturbs morphogenesis of the gastric lobe of the pancreas
PLOS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (6) : e21753-
Hörnblad, Andreas; Eriksson, Anna; Sock, Elisabeth; et al.
Growth-limiting role of endothelial cells in endoderm development
Developmental Biology, Academic Press 2011, Vol. 352, (2) : 267-277
Sand, Fredrik Wolfhagen; Hörnblad, Andreas; Johansson, Jenny K; et al.
Approaches for imaging islets
Advances in Experimental Medicine and Biology, Springer Netherlands 2010, Vol. 654 : 39-57
Ahlgren, Ulf; Gotthardt, Martin
Quantification and 3-D imaging of the insulitis-induced destruction of β-cells in murine type 1 diabetes
Diabetes, Vol. 59, (7) : 1756-1764
Alanentalo, Tomas; Hörnblad, Andreas; Mayans, Sofia; et al.
Optical imaging of islets: new possibilities by the development of infrared fluorescent proteins
Islets, Vol. 1, (2) : 163-164
Ahlgren, Ulf; Hörnblad, Andreas
FGF signals induce Caprin2 expression in the vertebrate lens.
Differentiation, Vol. 77, (4) : 386-394
Lorén, Christina E; Schrader, John W; Ahlgren, Ulf; et al.
High-resolution three-dimensional imaging of islet-infiltrate interactions based on optical projection tomography assessments of the intact adult mouse pancreas
Journal of Biomedical Optics, Bellingham, WA: SPIE--the International Society for Optical Engineering 2008, Vol. 13, (5) : 054070-
Alanentalo, Tomas; Lorén, Christina E; Larefalk, Asa; et al.
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Forskargrupper

Forskningsledare
Ulf Ahlgren
Ulf Ahlgren: Diabetes i nytt ljus – ny teknik ger ny kunskap

Med egenutvecklade ljusmikroskopiska tekniker studerar Ulf Ahlgren och hans forskargrupp diabetes, närmare bes...

Professor Ulf Ahlgren har tilldelats ett forskningsanslag på 2 000 000 kronor
Ulf Ahlgren tilldelas 2 000 000 kronor från Diabetes Wellness Sverige

"High resolution optical 3D imaging to understand human diabetes pathophysiology in a whole organ context"