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Umeå universitet
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Personalbild Sjoerd Wanrooij

Sjoerd Wanrooij

Min forskning fhandlar om molekylära mekanismer för DNA-reparation och replikering i mänskliga mitokondrier.

Vetenskaplig meritering: Docent

Kontakt

E-post
sjoerd.wanrooij@umu.se
Telefon
072-246 03 09

Verksam som

Anknytning
Universitetslektor vid Institutionen för medicinsk kemi och biofysik Roll: Biträdande prefekt
Plats
KB. A6, Campus, Umeå Umeå universitet, 901 87 Umeå

Förändringar i mitokondriellt DNA ger upphov till en mängd neuromuskulära symtom och ansamlas vid ärftliga mitokondriella sjukdomar, men även i drabbade vävnader hos patienter med Parkinsons sjukdom.

MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses
Molecular Biology of the Cell, American Society for Cell Biology (ASCB) 2025, Vol. 36, (2)
Aasumets, Koit; Hangas, Anu; Fragkoulis, Georgios; et al.
Linker design principles for the precision targeting of oncogenic G-quadruplex DNA with G4-ligand-conjugated oligonucleotides
Bioconjugate chemistry, American Chemical Society (ACS) 2025, Vol. 36, (4) : 724-736
Abrahamsson, Alva; Berner, Andreas; Golebiewska-Pikula, Justyna; et al.
Activating AMPK improves pathological phenotypes due to mtDNA depletion
The FEBS Journal, John Wiley & Sons 2025, Vol. 292, (9) : 2359-2380
Carvalho, Gustavo; Nguyen, Tran V. H.; Repolês, Bruno Marçal; et al.
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2025, Vol. 122, (16)
Forslund, Josefin M.E.; Nguyen, Tran V. H.; Parkash, Vimal; et al.
TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA
Communications Biology, Springer Nature 2025, Vol. 8, (1)
Matsuda, Shigeru; Nakayama, Masunari; Do, Yura; et al.
Exploring the dispersion and electrostatic components in arene-arene interactions between ligands and G4 DNA to develop G4-ligands
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2024, Vol. 67, (3) : 2202-2219
Andréasson, Måns; Donzel, Maxime; Abrahamsson, Alva; et al.
G4-ligand-conjugated oligonucleotides mediate selective binding and stabilization of individual G4 DNA structures
Journal of the American Chemical Society, American Chemical Society (ACS) 2024, Vol. 146, (10) : 6926-6935
Berner, Andreas; Das, Rabindra Nath; Bhuma, Naresh; et al.
Preferential binding of ADP-bound mitochondrial HSP70 to the nucleotide exchange factor GRPEL1 over GRPEL2
Protein Science, John Wiley & Sons 2024, Vol. 33, (11)
Manjunath, Pooja; Stojkovic, Gorazd; Euro, Liliya; et al.
Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model
International Journal of Molecular Sciences, MDPI 2023, Vol. 24, (14)
Akhunzianov, Almaz A.; Nesterova, Alfiya I.; Wanrooij, Sjoerd; et al.
Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (14) : 7392-7408
Doimo, Mara; Chaudhari, Namrata; Abrahamsson, Sanna; et al.
Rolling circle replication and bypass of damaged nucleotides
Mitochondrial DNA: methods and protocols, New York: Humana Press 2023 : 203-217
Forslund, Josefin M. E.; Stojkovič, Gorazd; Wanrooij, Sjoerd
TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication
Biochimica et Biophysica Acta. Molecular Cell Research, Elsevier 2022, Vol. 1869, (1)
Inatomi, Teppei; Matsuda, Shigeru; Ishiuchi, Takashi; et al.
A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells
Chemical Science, Royal Society of Chemistry 2022, Vol. 13, (8) : 2347-2354
Prasad, Bagineni; Doimo, Mara; Andréasson, Måns; et al.
Motif WFYY of human PrimPol is crucial to stabilize the incoming 3'-nucleotide during replication fork restart
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (14) : 8199-8213
Calvo, Patricia A; Martínez-Jiménez, María I; Díaz, Marcos; et al.
Human polymerase δ-interacting protein 2 (Poldip2) inhibits the formation of human tau oligomers and fibrils
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (11)
Kasho, Kazutoshi; Krasauskas, Lukas; Smirnovas, Vytautas; et al.
A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (4) : 2179-2191
Kasho, Kazutoshi; Stojkovic, Gorazd; Velázquez-Ruiz, Cristina; et al.
MtDNA replication, maintenance, and nucleoid organization
The human mitochondrial genome: from basic biology to disease, Academic Press 2020 : 3-33
Doimo, Mara; Pfeiffer, Annika; Wanrooij, Paulina H.; et al.
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
Photoactivated Colibactin Probes Induce Cellular DNA Damage
Angewandte Chemie International Edition, Vol. 58, (5) : 1417-1421
Moodie, Lindon W. K.; Hubert, Madlen; Zhou, Xin; et al.
A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (18) : 9471-9483
Al-Behadili, Ali; Uhler, Jay P.; Berglund, Anna-Karin; et al.
The presence of rNTPs decreases the speed of mitochondrial DNA replication
PLOS Genetics, Public library science 2018, Vol. 14, (3)
Forslund, Josefin M. E.; Pfeiffer, Annika; Stojkovič, Gorazd; et al.
Known Unknowns of Mammalian Mitochondrial DNA Maintenance
Bioessays, Wiley-Blackwell 2018, Vol. 40, (9)
Pohjoismäki, Jaakko L. O.; Forslund, Josefin; Goffart, Steffi; et al.
Optimization of the expression, purification and polymerase activity reaction conditions of recombinant human PrimPol
PLOS ONE, PUBLIC LIBRARY SCIENCE 2017, Vol. 12, (9)
Boldinova, Elizaveta O.; Stojkovic, Gorazd; Khairullin, Rafil; et al.
DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol
International Journal of Molecular Sciences, MDPI AG 2017, Vol. 18, (7)
Boldinova, Elizaveta O.; Wanrooij, Paulina H.; Shilkin, Evgeniy S.; et al.
PrimPol is required for replication reinitiation after mtDNA damage
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (43) : 11398-11403
Torregrosa-Muñumer, Rubén; Forslund, Josefin M. E.; Goffart, Steffi; et al.
Ribonucleotides incorporated by the yeast mitochondrial DNA polymerase are not repaired
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Oxidative DNA damage stalls the human mitochondrial replisome
Scientific Reports, Vol. 6
Stojkovic, Gorazd; Makarova, Alena V.; Wanrooij, Paulina H.; et al.
ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells
Biochimica et Biophysica Acta. Molecular Cell Research, Vol. 1853, (10) : 2580-2591
Al-Furoukh, Natalie; Ianni, Alessandro; Nolte, Hendrik; et al.
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication
PLOS Genetics, Vol. 10, (12) : e1004832-
Miralles Fusté, Javier; Shi, Yonghong; Wanrooij, Sjoerd; et al.
The Synergism of the Dispersion and Electrostatic Components in the Arene-Arene Interactions Between Ligands and G4 DNA
Andréasson, Måns; Donzel, Maxime; Abrahamsson, Alva; et al.
Development of a G4 Ligand-Conjugated Oligonucleotide Modality that Selectively Targets Individual G4 DNA Structures
Das, Rabindra Nath; Berner, Andreas; Bhuma, Naresh; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Sjoerd Wanrooij lab