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Umeå universitet
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Personalbild Pernilla Wikström

Pernilla Wikström

Vetenskaplig meritering: Docent

Kontakt

E-post
pernilla.wikstrom@umu.se
Telefon
090-785 37 52

Verksam som

Anknytning
Professor vid Institutionen för medicinsk biovetenskap Enhet: Patologi
Plats
By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå
Anknytning
Övrig/annan befattning vid Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM) Roll: Biträdande föreståndare
Plats
Umeå universitet, 901 87 Umeå
Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models
Molecular Oncology, John Wiley & Sons 2025, Vol. 19, (11) : 3035-3059
Classon, Johanna; Stenudd, Moa; Zamboni, Margherita; et al.
Metabolic readouts of tumor instructed normal tissues (TINT) identify aggressive prostate cancer subgroups for tailored therapy
Frontiers in Molecular Biosciences, Frontiers Media S.A. 2025, Vol. 12
Dudka, Ilona; Figueira, Joao; Wikström, Pernilla; et al.
Morphological heterogeneities in prostate cancer bone metastases are related to molecular subtypes and prognosis
Clinical and Experimental Metastasis, Springer Nature 2025, Vol. 42, (5)
Halin Bergström, Sofia; Semenas, Julius; Nordstrand, Annika; et al.
Adverse prognosis gene expression patterns in metastatic castration-resistant prostate cancer
Molecular Oncology, John Wiley & Sons 2025, Vol. 19, (8) : 2348-2365
Sharifi, Marina N.; Feng, Eric; Rydzewski, Nicholas R.; et al.
Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling
Frontiers in Immunology, Frontiers Media S.A. 2024, Vol. 15
Henning, Petra; Kassem, Ali; Westerlund, Anna; et al.
Molekylära subtyper och avancerad prostatacancer: nya möjligheter för anpassad behandling: [Molecular subtypes provide possibilities for precision medicine in a advanced prostate cancer]
Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121
Wikström, Pernilla; Bergh, Anders; Josefsson, Andreas; et al.
Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes
Journal of Translational Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)
Dudka, Ilona; Lundquist, Kristina; Wikström, Pernilla; et al.
Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328
Cancers, MDPI 2023, Vol. 15, (9)
Järemo, Helena; Semenas, Julius; Halin Bergström, Sofia; et al.
Ki67 and prostate specific antigen are prognostic in metastatic hormone naïve prostate cancer
Acta Oncologica, Taylor & Francis 2023, Vol. 6212 : 1698-1706
Spyratou, Vasiliki; Freyhult, Eva; Bergh, Anders; et al.
A novel radiographic pattern related to poor prognosis in patients with prostate cancer with metastatic spinal cord compression
European Urology Open Science, Elsevier 2023, Vol. 48 : 44-53
Wänman, Johan; Abul-Kasim, Kasim; Semenas, Julius; et al.
Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer
NAR Cancer, Oxford University Press 2023, Vol. 5, (3)
Zivanovic, Andrej; Miller, Jeffrey T.; Munro, Sarah A.; et al.
Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C
Molecular Oncology, John Wiley & Sons 2022, (4)
Thysell, Elin; Köhn, Linda; Semenas, Julius; et al.
Epithelial and stromal characteristics of primary tumors predict the bone metastatic subtype of prostate cancer and patient survival after androgen-deprivation therapy
Cancers, MDPI 2022, Vol. 14, (21)
Wikström, Pernilla; Halin Bergström, Sofia; Josefsson, Andreas; et al.
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer
Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
High-grade tumours promote growth of other less-malignant tumours in the same prostate
Journal of Pathology, John Wiley & Sons 2021, Vol. 253, (4) : 396-403
Halin Bergström, Sofia; Rudolfsson, Stina H.; Lundholm, Marie; et al.
Klk4t2 is a hormonally regulated transcript from the klk4 locus
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (23)
Lundwall, Åke; Bovinder Ylitalo, Erik; Wikström, Pernilla; et al.
High monocyte count and expression of s100a9 and s100a12 in peripheral blood mononuclear cells are associated with poor outcome in patients with metastatic prostate cancer
Cancers, MDPI 2021, Vol. 13, (10)
Åberg, Anna-Maja; Halin Bergström, Sofia; Thysell, Elin; et al.
Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens
The Prostate, John Wiley & Sons 2020, Vol. 80, (2) : 214-224
Bovinder Ylitalo, Erik; Thysell, Elin; Thellenberg-Karlsson, Camilla; et al.
Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status
BMC Cancer, BioMed Central 2020, Vol. 20, (1)
Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; et al.
Tumor-educated platelets for early prostate cancer diagnosis, and therapy stratification in patients with metastasized castration resistant prostate cancer
Clinical Cancer Research, American Association for Cancer Research 2020, Vol. 26, (11) : 73-74
Tjon-Kon-Fat, Lee-Ann; Köhn, Linda; Best, Myron; et al.
Regulation of cell-cell adhesion in prostate cancer cells by microRNA-96 through upregulation of E-Cadherin and EpCAM
Carcinogenesis, Oxford University Press 2020, Vol. 41, (7) : 865-874
Voss, Gjendine; Haflidadottir, Benedikta S.; Järemo, Helena; et al.
Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome
Modern Pathology, Vol. 32, (9) : 1310-1319
Hammarsten, Peter; Josefsson, Andreas; Thysell, Elin; et al.
Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation
The FASEB Journal, Federation of American Societies for Experimental Biology 2019, Vol. 33, (4) : 5237-5247
Lionikaite, Vikte; Henning, Petra; Drevinge, Christina; et al.
Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor
Molecular Oncology, John Wiley & Sons 2019, Vol. 13, (8) : 1763-1777
Thysell, Elin; Vidman, Linda; Bovinder Ylitalo, Erik; et al.
Bone remodeling in relation to androgen receptor activity in prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 50-50
Bovinder Ylitalo, Erik; Nordstrand, Annika; Thysell, Elin; et al.
High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer
Scandinavian journal of urology, Taylor & Francis 2018, Vol. 52, (2) : 129-133
Erlandsson, Ann; Carlsson, Jessica; Andersson, Sven-Olof; et al.
The proteome of prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 91-92
Iglesias-Gato, Diego; Thysell, Elin; Crnalic, Sead; et al.
The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications
Clinical Cancer Research, American Association for Cancer Research 2018, Vol. 24, (21) : 5433-5444
Iglesias-Gato, Diego; Thysell, Elin; Tyanova, Stefka; et al.
Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (4)
Nordstrand, Annika; Bovinder Ylitalo, Erik; Thysell, Elin; et al.
Clinically relevant molecular subgroups of prostate cancer bone metastases
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 123-123
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients
The Prostate, Wiley-Blackwell 2018, Vol. 78, (1) : 48-53
Tjon-Kon-Fat, Lee-Ann; Lundholm, Marie; Schröder, Mona; et al.
Subgroups of castration-resistant prostate cancer bone metastases defined through an inverse relationship between androgen receptor activity and immune response
European Urology, Vol. 71, (5) : 776-787
Bovinder Ylitalo, Erik; Thysell, Elin; Jernberg, Emma; et al.
High Levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases
The Prostate, Wiley-Blackwell Publishing Inc. 2017, Vol. 77, (6) : 625-638
Djusberg, Erik; Jernberg, Emma; Thysell, Elin; et al.
Clinical relevance of androgen receptor alterations in prostate cancer
Endocrine Connections, Vol. 6, (8) : R146-R161
Jernberg, Emma; Bergh, Anders; Wikström, Pernilla
Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone
Clinical and Experimental Metastasis, Springer 2017, Vol. 34, (3-4) : 261-271
Nordstrand, Annika; Halin Bergström, Sofia; Thysell, Elin; et al.
Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival
Tumor Biology, SAGE PUBLICATIONS LTD 2017, Vol. 39, (2)
Svenson, Ulrika; Roos, Göran; Wikström, Pernilla
A Systems Approach to Prostate Cancer Classification: Letter
Cancer Research, American Association for Cancer Research 2017, Vol. 77, (24) : 7131-7132
Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology, ELSEVIER SCIENCE BV 2017, Vol. 72, (4) : e104-e105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87
European Urology, Elsevier 2017, Vol. 72, (4) : E104-E105
Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.
Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Halin Bergström, Sofia; Hägglöf, Christina; Thysell, Elin; et al.
Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth
PLOS ONE, Vol. 11, (6)
Halin Bergström, Sofia; Nilsson, Maria; Adamo, Hanibal; et al.
High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting
PLOS ONE, Vol. 11, (10)
Hammarsten, Peter; Scherdin, Tove Dahl; Hagglöf, Christina; et al.
The Proteome of Primary Prostate Cancer
European Urology, Vol. 69, (5) : 942-952
Iglesias-Gato, Diego; Wikström, Pernilla; Tyanova, Stefka; et al.
OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo
Molecular Cancer, BioMed Central (BMC) 2015, Vol. 14
Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.
Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (vol 14, 8, 2015)
Molecular Cancer, Vol. 14, (1)
Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.
Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples
Metabolomics, Springer 2015, Vol. 11, (6) : 1667-1678
Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.
Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Lundholm, Marie; Hägglöf, Christina; Wikberg, Maria L.; et al.
High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting
PLOS ONE, Public library science 2015, Vol. 10, (10)
Nilsson, Maria; Hägglöf, Christina; Hammarsten, Peter; et al.
SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer
Carcinogenesis, Oxford University Press 2014, Vol. 35, (1) : 24-33
Iglesias-Gato, Diego; Chuan, Yin-Choy; Wikström, Pernilla; et al.
Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion
PLOS ONE, Vol. 9, (9) : e108925-
Lundholm, Marie; Schröder, Mona; Nagaeva, Olga; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Pernilla Wikströms labb

Forskningsprojekt

1 september 2023
SPRINTR projekt
1 augusti 2020 till 31 december 2027
APACA-studien: Kan CTC fungera som ett surrogat för biopsier från metastaser?
1 januari 2019 till 31 december 2022
Biomarkörer för säkrare prognostisering och förbättrad behandling av aggressiv prostatacancer
28 februari 2007 till 31 december 2010
Biomarkörer för aggressiv prostatacancer