Du surfar just nu på en begränsad version av umu.se. Vad innebär det här?

"False"
Umeå universitet
printicon
Huvudmenyn dold.
Personalbild Erik Johansson

Erik Johansson

Professor i medicinsk kemi

Prefekt vid instititutionen för medicinsk kemi och biofysik

0000-0002-8526-6224

Kontakt

E-post
erik.tm.johansson@umu.se
Telefon
090-786 66 38, 072-205 93 20

Verksam som

Anknytning
Professor vid Institutionen för medicinsk kemi och biofysik Roll: Prefekt
Plats
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2025, Vol. 122, (16)
Forslund, Josefin M.E.; Nguyen, Tran V. H.; Parkash, Vimal; et al.
Decoding nucleoside supplementation: how thymidine outperforms ribonucleosides in accelerating mammalian replication forks
Nucleic Acids Research, Oxford University Press 2025, Vol. 53, (19)
Pandey, Praveen; Kurashima, Kiminori; Bylund, Göran; et al.
Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish
Communications Biology, Nature Publishing Group 2024, Vol. 7, (1)
Lawir, Divine-Fondzenyuy; Soza-Ried, Cristian; Iwanami, Norimasa; et al.
Clamping Pol ε to the leading strand
Nature Structural & Molecular Biology, Springer Nature 2024, Vol. 31, (11) : 1644-1645
Singh, Noopur; Johansson, Erik
A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (20) : 11225-11238
Parkash, Vimal; Kulkarni, Yashraj; Bylund, Göran O.; et al.
Enhanced polymerase activity permits efficient synthesis by cancer-Associated DNA polymerase variants at low dNTP levels
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (14) : 8023-8040
Barbari, Stephanie R.; Beach, Annette K.; Markgren, Joel G.; et al.
Unchecked nick ligation can promote localized genome re-replication
Current Biology, Elsevier 2021, Vol. 31, (11) : R710-R711
Johansson, Erik; Diffley, John F X
The [4Fe4S] Cluster of Yeast DNA Polymerase ϵ Is Redox Active and Can Undergo DNA-Mediated Signaling
Journal of the American Chemical Society, American Chemical Society (ACS) 2021, Vol. 143, (39) : 16147-16153
Pinto, Miguel N.; ter Beek, Josy; Ekanger, Levi A.; et al.
Eukaryotic DNA replication with purified budding yeast proteins
The DNA replication-repair interface, Elsevier 2021 : 1-33
Posse, Viktor; Johansson, Erik; Diffley, John F. X.
A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
PLOS ONE, Public Library Science 2020, Vol. 15, (9)
Svensson, Daniel; Rentoft, Matilda; Dahlin, Anna M.; et al.
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon
Nature Communications, Nature Publishing Group 2019, Vol. 10
Parkash, Vimal; Kulkarni, Yashraj; ter Beek, Josy; et al.
A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis
PLOS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (11) : 5712-5722
ter Beek, Josy; Parkash, Vimal; Bylund, Göran; et al.
A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
Strand displacement synthesis by yeast DNA polymerase epsilon
Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (17) : 8229-8240
Ganai, Rais A.; Zhang, Xiao-Ping; Heyer, Wolf-Dietrich; et al.
DNA Replication - A Matter of Fidelity
Molecular Cell, Vol. 62, (5) : 745-755
Ganai, Rais Ahmad; Johansson, Erik
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (17) : 4723-4728
Rentoft, Matilda; Lindell, Kristoffer; Tran, Phong; et al.
Switching between polymerase and exonuclease sites in DNA polymerase ε
Nucleic Acids Research, Oxford University Press 2015, Vol. 43, (2) : 932-942
Ganai, Rais Ahmad; Bylund, Göran; Johansson, Erik
Yeast DNA Polymerase epsilon Catalytic Core and Holoenzyme Have Comparable Catalytic Rates
Journal of Biological Chemistry, USA: 2015, Vol. 290, (6) : 3825-3835
Ganai, Rais Ahmad; Osterman, Pia; Johansson, Erik
Mammalian POLQ, Chromosome Stability and DNA Double-Strand Break Repair
Environmental and Molecular Mutagenesis, Vol. 56 : S48-S48
Yousefzadeh, M. J.; Wyatt, D. W.; Takata, K.; et al.
Structural basis for processive DNA synthesis by yeast DNA polymerase ε
Nature Structural & Molecular Biology, Nature Publishing Group 2014, Vol. 21, (1) : 49-56
Hogg, Matthew; Osterman, Pia; Bylund, Göran; et al.
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ
PLOS Genetics, Public library science 2014, Vol. 10, (10) : e1004654-
Yousefzadeh, Matthew J; Wyatt, David W; Takata, Kei-Ichi; et al.
DNA och cancerutveckling
Cancerforskning på nya vägar: en bok från Froskningens dag 2013, Medicinska fakulteten vid Umeå universitet, Umeå: Umeå universitet 2013 : 15-22
Johansson, Erik
Replicative DNA polymerases
Cold Spring Harbor Perspectives in Biology, Vol. 5, (6) : a012799-
Johansson, Erik; Dixon, Nicholas
DNA Polymerase ε
The eukaryotic replisome: a guide to protein structure and function, Springer Science+Business Media B.V. 2012 : 237-57
Hogg, Matthew; Johansson, Erik
Promiscuous DNA synthesis by human DNA polymerase θ
Nucleic Acids Research, Vol. 40, (6) : 2611-2622
Hogg, Matthew; Sauer-Eriksson, A Elisabeth; Johansson, Erik
The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability
Nucleic Acids Research, Vol. 40, (22) : 11545-11553
Isoz, Isabelle; Persson, Ulf; Volkov, Kirill; et al.
RNase H2-Initiated Ribonucleotide Excision Repair
Molecular Cell, Vol. 47, (6) : 980-986
Sparks, Justin L; Chon, Hyongi; Cerritelli, Susana M; et al.
Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ.
DNA Repair, Vol. 11, (8) : 649-656
Williams, Jessica S; Clausen, Anders R; Nick McElhinny, Stephanie A; et al.
A top-down view on DNA replication and recombination from 9,000 feet above sea level
Genome Biology, BioMed Central 2011, Vol. 12, (4)
Johansson, Erik; Speck, Christian; Chabes, Andrei
Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases
DNA Repair, Vol. 10, (8) : 897-902
Watt, Danielle L; Johansson, Erik; Burgers, Peter M; et al.
Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε
PLoS genetics, Public Library of Science 2010, Vol. 6, (11) : e1001209-
Aksenova, Anna; Volkov, Kirill; Maceluch, Jaroslaw; et al.
The eukaryotic replicative DNA polymerases take shape.
TIBS -Trends in Biochemical Sciences. Regular ed., Elsevier 2010, Vol. 35, (6) : 339-347
Johansson, Erik; MacNeill, Stuart A
Genome instability due to ribonucleotide incorporation into DNA
Nature Chemical Biology, Vol. 6, (10) : 774-81
Nick McElhinny, Stephanie A; Kumar, Dinesh; Clark, Alan B; et al.
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, (11) : 4949-4954
Nick McElhinny, Stephanie A; Watts, Brian E; Kumar, Dinesh; et al.
Translesion synthesis of abasic sites by yeast DNA polymerase epsilon
The Journal of biological chemistry, Vol. 284, (46) : 31555-31563
Sabouri, Nasim; Johansson, Erik
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
Nucleic Acids Research, Vol. 36, (17) : 5660-5667
Sabouri, Nasim; Viberg, Jörgen; Kumar, Dinesh; et al.
Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya.
Nucleic Acids Research, Vol. 36, (3) : 705-711
Wardle, Josephine; Burgers, Peter M J; Cann, Isaac K O; et al.
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.
Nucleic Acids Research, Vol. 35, (19) : 6588-6597
Chilkova, Olga; Stenlund, Peter; Isoz, Isabelle; et al.
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.
Nucleic Acids Research, Vol. 35, (9) : 3076-3086
Pursell, Zachary F; Isoz, Isabelle; Lundström, Else-Britt; et al.
Yeast DNA polymerase epsilon participates in leading-strand DNA replication.
Science, Vol. 317, (5834) : 127-130
Pursell, Zachary F; Isoz, Isabelle; Lundström, Else-Britt; et al.
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.
Nature Structural & Molecular Biology, Vol. 13, (1) : 35-43
Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; et al.
Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.
Journal of biological chemistry, Vol. 280, (33) : 29980-7
Fortune, John M; Pavlov, Youri I; Welch, Carrie M; et al.
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.
Genes & Development, Vol. 18, (22) : 2764-2773
Garg, Parie; Stith, Carrie M; Sabouri, Nasim; et al.
The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding.
Journal of biological chemistry, Vol. 279, (3) : 1907-15
Johansson, Erik; Garg, Parie; Burgers, Peter M J
Enzymatic switching for efficient and accurate translesion DNA replication.
Nucleic Acids Research, Vol. 32, (15) : 4665-75
McCulloch, Scott D; Kokoska, Robert J; Chilkova, Olga; et al.
The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.
Journal of Biological Chemistry, Vol. 278, (16) : 14082-14086
Chilkova, Olga; Jonsson, Bengt-Harald; Johansson, Erik
Unique error signature of the four-subunit yeast DNA polymerase epsilon.
Journal of Biological Chemistry, Vol. 278, (44) : 43770-43780
Shcherbakova, Polina V; Pavlov, Youri I; Chilkova, Olga; et al.
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.
Genes & Development, Vol. 15, (8) : 945-54
Haracska, L; Unk, I; Johnson, R E; et al.
Structure of DNA polymerase delta from Saccharomyces cerevisiae.
Journal of Biological Chemistry, Vol. 276, (47) : 43824-8
Johansson, Erik; Majka, J; Burgers, P M
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Erik Johansson lab

Forskningsprojekt

1 januari 2022 till 31 december 2024
Kopiering av arvsmassan hos celler
1 juli 2000 till 31 december 2021
Kopiering och reparation av cellens arvsmassa