Xiaolian Gu

Contact

xiaolian.gu@umu.se

+46 90 785 27 87

Works as

Staff scientist at Department of Medical Biosciences Section: Pathology

By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

A unique plasma protein signature characterizes squamous cell carcinoma of the oral tongue in young adults

Journal of Oral Pathology & Medicine, John Wiley & Sons 2025, Vol. 54, (8) : 706-714

Gu, Xiaolian; Coates, Philip J.; Wang, Lixiao; et al.

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

British Journal of Cancer, Springer Nature 2025, Vol. 133 : 970-975

Sajwan, Rhythm; Wang, Lixiao; Casar-Borota, Olivera; et al.

Automated tumor-stroma ratio estimation for improved prognostic stratification of squamous cell carcinoma of the oral tongue

The journal of pathology. Clinical research, Vol. 11, (4)

Wang, Lixiao; Sörensen, Katrine; Coates, Philip J; et al.

Upregulation of apoptosis related genes in clinically normal tongue contralateral to squamous cell carcinoma of the oral tongue, an effort to maintain tissue homeostasis

Head and neck pathology, Springer Nature 2024, Vol. 18, (1)

Attaran, Nima; Coates, Philip J.; Zborayova, Katarina; et al.

Patients with oral tongue squamous cell carcinoma and co‑existing diabetes exhibit lower recurrence rates and improved survival: implications for treatment

Oncology Letters, Spandidos Publications 2024, Vol. 27, (4)

Salehi, Amir M.; Wang, Lixiao; Gu, Xiaolian; et al.

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Cell Death and Differentiation, Springer Nature 2023, Vol. 30 : 1072-1081

Fusée, Leila; Salomao, Norman; Ponnuswamy, Anand; et al.

Early detection of squamous cell carcinoma of the oral tongue using multidimensional plasma protein analysis and interpretable machine learning

Journal of Oral Pathology & Medicine, John Wiley & Sons 2023, Vol. 52, (7) : 637-643

Gu, Xiaolian; Salehi, Amir M.; Wang, Lixiao; et al.

Evidence for etiologic field changes in tongue distant from tumor in patients with squamous cell carcinoma of the oral tongue

Journal of Pathology, John Wiley & Sons 2023, Vol. 259, (1) : 93-102

Gu, Xiaolian; Wang, Lixiao; Coates, Philip J.; et al.

Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia

British Journal of Haematology, John Wiley & Sons 2023, Vol. 201, (2) : 234-248

Salomao, Norman; Maslah, Nabih; Giulianelli, Anouk; et al.

Antigen peptide transporters are upregulated in squamous cell carcinoma of the oral tongue and show sex‑specific associations with survival

Oncology Letters, Spandidos Publications 2022, Vol. 24, (5)

Attaran, Nima; Coates, Philip; Zborayova, Katarina; et al.

Reiterative modeling of combined transcriptomic and proteomic features refines and improves the prediction of early recurrence in squamous cell carcinoma of head and neck

Computers in Biology and Medicine, Elsevier 2022, Vol. 149

Salehi, Amir M.; Wang, Lixiao; Coates, Philip J.; et al.

An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers

Journal of Experimental & Clinical Cancer Research, BioMed Central (BMC) 2022, Vol. 41, (1)

Wang, Bo; Gan, Jiaxing; Liu, Zhengyan; et al.

Low potential of circulating interleukin 1 receptor antagonist as a prediction marker for squamous cell carcinoma of the head and neck

Journal of Oral Pathology & Medicine, John Wiley & Sons 2021, Vol. 50, (8) : 785-794

Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.

Variation in Plasma Levels of TRAF2 Protein During Development of Squamous Cell Carcinoma of the Oral Tongue

Frontiers in Oncology, Frontiers Media S.A. 2021, Vol. 11

Gu, Xiaolian; Coates, Philip; Wang, Lixiao; et al.

High Levels of Low-Density Lipoproteins Correlate with Improved Survival in Patients with Squamous Cell Carcinoma of the Head and Neck

Biomedicines, MDPI 2021, Vol. 9, (5)

Wilms, Torben; Boldrup, Linda; Gu, Xiaolian; et al.

Downregulation of TAP1 in Tumor-Free Tongue Contralateral to Squamous Cell Carcinoma of the Oral Tongue, an Indicator of Better Survival.

International Journal of Molecular Sciences, MDPI 2020, Vol. 21, (17)

Attaran, Nima; Gu, Xiaolian; Coates, Philip J; et al.

Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck

Oncology Letters, Spandidos Publications 2020, Vol. 20, (2) : 1709-1718

Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.

Transfer-RNA-Derived Fragments Are Potential Prognostic Factors in Patients with Squamous Cell Carcinoma of the Head and Neck

Genes, MDPI 2020, Vol. 11, (11)

Gu, Xiaolian; Wang, Lixiao; Coates, Philip J.; et al.

PD-L1 in squamous cell carcinoma of the oral tongue shows gender-specific association with prognosis

Oral Diseases, John Wiley & Sons 2020, Vol. 26, (7) : 1414-1423

Wilms, Torben; Gu, Xiaolian; Boldrup, Linda; et al.

High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

The journal of pathology. Clinical research, John Wiley & Sons 2019, Vol. 5, (4) : 240-247

Gu, Xiaolian; Boldrup, Linda; Coates, Philip J.; et al.

Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue

Journal of Oral Pathology & Medicine, John Wiley & Sons 2019, Vol. 48, (1) : 24-30

Gu, Xiaolian; Coates, Philip J.; Boldrup, Linda; et al.

AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck

Cancers, MDPI 2019, Vol. 11, (3)

Gu, Xiaolian; Wang, Lixiao; Boldrup, Linda; et al.

Searching for new targets and treatments in the battle against squamous cell carcinoma of the head and neck, with specific focus on tumours of the tongue

Current Topics in Medicinal Chemistry, Bentham Science Publishers 2018, Vol. 18, (3) : 214-218

Sgaramella, Nicola; Gu, Xiaolian; Boldrup, Linda; et al.

Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue

Oncology Letters, Spandidos Publications 2018, Vol. 16, (5) : 6603-6607

Sgaramella, Nicola; Wilms, Torben; Boldrup, Linda; et al.

Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma

Oncotarget, Vol. 8, (12) : 19389-19402

Boldrup, Linda; Gu, Xiaolian; Coates, Philip J.; et al.

Evidence that circulating proteins are more promising than miRNAs for identification of patients with squamous cell carcinoma of the tongue

Oncotarget, IMPACT JOURNALS LLC 2017, Vol. 8, (61) : 103437-103448

Boldrup, Linda; Troiano, Giuseppe; Gu, Xiaolian; et al.

Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours

Journal of Oral Pathology & Medicine, John Wiley & Sons 2017, Vol. 46, (10) : 967-971

Strindlund, Klas; Troiano, Giuseppe; Sgaramella, Nicola; et al.

Expression of the long non-coding RNA HOTAIR as a prognostic factor in squamous cell carcinoma of the head and neck: a systematic review and meta-analysis

Oncotarget, Impact Journals LLC 2017, Vol. 8, (42) : 73029-73036

Troiano, Giuseppe; Caponio, Vito Carlo Alberto; Boldrup, Linda; et al.

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Scientific Reports, Vol. 6

Gu, Xiaolian; Boldrup, Linda; Coates, Philip J; et al.

Delta Np63 alpha expression induces loss of cell adhesion in triple-negative breast cancer cells

BMC Cancer, BioMed Central 2016, Vol. 16

Nekulova, Marta; Holcakova, Jitka; Gu, Xiaolian; et al.

Circulating miRNAs from blood, plasma or serum as promising clinical biomarkers in oral squamous cell carcinoma: A systematic review of current findings

Oral Oncology, Vol. 63 : 30-37

Troiano, Giuseppe; Boldrup, Linda; Ardito, Fatima; et al.

Correlation between Reversal of DNA Methylation and Clinical Symptoms in Psoriatic Epidermis Following Narrow-Band UVB Phototherapy

Journal of Investigative Dermatology, Vol. 135, (8) : 2077-2083

Gu, Xiaolian; Nylander, Elisabet; Coates, Philip J.; et al.

Oxidation Reduction is a Key Process for Successful Treatment of Psoriasis by Narrow-band UVB Phototherapy

Acta Dermato-Venereologica, Vol. 95, (2) : 140-146

Gu, Xiaolian; Nylander, Elisabet; Coates, Philip J.; et al.

Wilms' tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck

BMC Cancer, Vol. 15

Li, Xingru; Ottosson, Sofia; Wang, Sihan; et al.

Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus

Journal of Oral Pathology & Medicine, Vol. 41, (1) : 90-95

Danielsson, Karin; Wahlin, Ylva-Britt; Gu, Xiaolian; et al.

Effect of narrow-band ultraviolet B phototherapy on p63 and microRNA (miR-21 and miR-125b) expression in psoriatic epidermis

Acta Dermato-Venereologica, Vol. 91, (4) : 392-397

Gu, Xiaolian; Nylander, Elisabet; Coates, Philip J; et al.

p63 and epithelial homeostasis: studies of p63 under normal, hyper-proliferative and malignant conditions

Umeå University medical dissertations, 1353

Gu, Xiaolian

Little effect on p63 but significant effect on miR-21 and miR-125b by NB-UVB phototherapy on psoriatic lesions

Gu, Xiaolian; Nylander, E; Coates, PJ; et al.

DeltaNp63 isoforms differentially regulate gene expression in squamous cell carcinoma: identification of Cox-2 as a novel p63 target.

The Journal of pathology

Boldrup, Linda; Coates, Philip J; Gu, Xiaolian; et al.

p63 contributes to cell invasion and migration in squamous cell carcinoma of the head and neck

Cancer Letters, Vol. 263, (1) : 26-34

Gu, Xiaolian; Coates, Philip J; Boldrup, Linda; et al.

DeltaNp63 isoforms regulate CD44 and keratins 4, 6, 14 and 19 in squamous cell carcinoma of head and neck.

J Pathol, Vol. 213, (4) : 384-91

Boldrup, Linda; Coates, Philip J; Gu, Xiaolian; et al.

TRAF4 is potently induced by TAp63 isoforms and localised according to differentiation in SCCHN

Cancer Biology & Therapy, Vol. 6, (12) : 1979-1983

Gu, Xiaolian; Coates, Philip; MacCallum, Stephanie; et al.

Exclusion of p63 as a candidate gene for autosomal-dominant amelogenesis imperfecta.

Acta Odontologica Scandinavica, Vol. 64, (2) : 111-114

Gu, Xiaolian; Bäckman, Birgitta; Coates, Philip J; et al.

Dysregulation of TAp63 mRNA and protein levels in psoriasis

Journal of Investigative Dermatology, Vol. 126, (1) : 137-141

Gu, Xiaolian; Lundqvist, Elisabet N; Coates, Philip J; et al.

Unveiling the prognostic potential of Wnt pathway antagonist SFRP4 in oral squamous cell carcinoma

Attaran, Nima; Magan, M.; Coats, PJ; et al.

View publications in DiVA

Research groups

Group member

Karin Nylander Lab