Sushma Sharma

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Works as

Staff scientist at Department of Medical Biochemistry and Biophysics Section: Andrei Chabes group

KB. H6, Campus, Umeå Umeå universitet, 901 87 Umeå

RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2025, Vol. 122, (16)

Awoyomi, Ololade Folajimi; Gorospe, Choco Michael; Das, Biswajit; et al.

Rapid remodeling of NTP levels enables immediate translational adaptation to energy stress in yeast

Molecular Cell, Elsevier 2025, Vol. 85, (19) : 3623-3639.e7.

Bexley, Katherine; Ristová, Michaela; Sharma, Sushma; et al.

Altered dNTP pools accelerate tumor formation in mice

Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (20) : 12475-12486

Tran, Phong; Mishra, Pradeep; Williams, Leonard G.; et al.

Physical interactions between specifically regulated subpopulations of the MCM and RNR complexes prevent genetic instability

PLOS Genetics, Public Library of Science (PLoS) 2024, Vol. 20, (5)

Yáñez-Vilches, Aurora; Romero, Antonia M.; Barrientos-Moreno, Marta; et al.

Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand

DNA Repair, Elsevier 2023, Vol. 129

Dmowski, Michal; Makiela-Dzbenska, Karolina; Sharma, Sushma; et al.

Quantitative analysis of nucleoside triphosphate pools in mouse muscle using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry detection

Mitochondrial DNA: methods and protocols, New York: Humana Press 2023 : 267-280

Sharma, Sushma; Kong, Ziqing; Jia, Shaodong; et al.

Chl1 helicase controls replication fork progression by regulating dNTP pools

Life Science Alliance, Vol. 5, (4)

Batté, Amandine; van der Horst, Sophie C.; Tittel-Elmer, Mireille; et al.

dNTP concentrations do not increase in mammalian cells in response to DNA damage

Cell Metabolism, Elsevier 2022, Vol. 34, (12) : 1895-1896

Das, Biswajit; Mishra, Pradeep; Pandey, Praveen; et al.

Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex

DNA Repair, Elsevier 2022, Vol. 110

Dmowski, Michal; Jedrychowska, Malgorzata; Makiela-Dzbenska, Karolina; et al.

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples

Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (3)

Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase

Nucleic Acids Research, Oxford Academic 2020, Vol. 48, (8) : 4274-4297

Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; et al.

SAMHD1 agit sur les fourches de réplication bloquées pour empêcher l’induction d’interféron: [SAMHD1 acts at stalled replication forks to prevent interferon induction]

Comptes rendus. Biologies, Académie des Sciences 2020, Vol. 343, (1) : 9-21

Coquel, F.; Silva, M. J.; Techer, H.; et al.

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Cell Reports, Elsevier 2020, Vol. 31, (6)

Davenne, Tamara; Klintman, Jenny; Sharma, Sushma; et al.

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication

Molecular Cell, Elsevier 2020, Vol. 78, (3) : 496-410.e4

Forey, Romain; Poveda, Ana; Sharma, Sushma; et al.

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277

Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.

Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos

Nature Metabolism, Nature Publishing Group 2020, Vol. 2, (8) : 673-675

Sharma, Sushma; Koolmeister, Camilla; Tran, Phong; et al.

Elimination of rNMPs from mitochondrial DNA has no effect on its stability

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313

Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.

Ribonucleotide reductase from Fusarium oxysporum does not Respond to DNA replication stress

DNA Repair, Elsevier 2019, Vol. 83

Cohen, Rotem; Milo, Shira; Sharma, Sushma; et al.

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity

Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (8) : 3986-3995

Garbacz, Marta A.; Cox, Phillip B.; Sharma, Sushma; et al.

Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats

PLOS Genetics, San Francisco: Public Library of Science 2019, Vol. 15, (8)

Li, Xiaoli; Jin, Xuejiao; Sharma, Sushma; et al.

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria

Molecular Cell, Elsevier 2019, Vol. 76, (5) : 784-+

Nicholls, Thomas J.; Spåhr, Henrik; Jiang, Shan; et al.

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance

Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (1) : 237-252

Schmidt, Tobias T.; Sharma, Sushma; Reyes, Gloria X.; et al.

De novo dNTP production is essential for normal postnatal murine heart development

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897

Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Nature Communications, Nature Publishing Group 2019, Vol. 10

Xing, Xuanxuan; Kane, Daniel P.; Bulock, Chelsea R.; et al.

Mrc1 and Rad9 cooperate to regulate initiation and elongation of DNA replication in response to DNA damage

EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (21)

Bacal, Julien; Moriel-Carretero, María; Pardo, Benjamin; et al.

SAMHD1 acts at stalled replication forks to prevent interferon induction

Nature, Vol. 557, (7703) : 57-61

Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; et al.

Separable roles for Mec1/ATR in genome maintenance, DNA replication, and checkpoint signaling

Genes & Development, Vol. 32, (11-12) : 822-835

Lanz, Michael Charles; Oberly, Susannah; Sanford, Ethan James; et al.

Rtt105 functions as a chaperone for replication protein A to preserve genome stability

EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (17)

Li, Shuqi; Xu, Zhiyun; Xu, Jiawei; et al.

Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, Vol. 8, (8) : 2551-2558

van Mourik, Paula M; de Jong, Jannie; Sharma, Sushma; et al.

A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-

Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.

Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress

Molecular Cell, Elsevier 2017, Vol. 68, (2) : 446-455

Gan, Haiyun; Yu, Chuanhe; Devbhandari, Sujan; et al.

Rnr1, but not Rnr3, facilitates the sustained telomerase-dependent elongation of telomeres

PLOS Genetics, Vol. 13, (10)

Maicher, André; Gazy, Inbal; Sharma, Sushma; et al.

Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis

Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : E4442-E4451

Schmidt, Tobias T; Reyes, Gloria; Gries, Kerstin; et al.

Polyphosphate is involved in cell cycle progression and genomic stability in Saccharomyces cerevisiae

Molecular Microbiology, Vol. 101, (3) : 367-380

Bru, Samuel; Marc Martinez-Lainez, Joan; Hernandez-Ortega, Sara; et al.

Determination of deoxyribonucleoside triphosphate concentrations in yeast cells by strong anion-exchange high-performance liquid chromatography coupled with ultraviolet detection

DNA Replikation: Methods and Protocols, New York: Springer-Verlag New York 2015 : 113-121

Jia, Shaodong; Marjavaara, Lisette; Buckland, Robert; et al.

Colon cancer-associated mutator DNA polymerase δ variant causes expansion of dNTP pools increasing its own infidelity

Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2467-E2476

Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; et al.

Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants

PLOS ONE, Vol. 9, (9)

Ragu, Sandrine; Dardalhon, Michele; Sharma, Sushma; et al.

Telomere Length Homeostasis Responds to Changes in Intracellular dNTP Pools

Genetics, The Genetics Society 2013, Vol. 193, (4) : 1095-1105

Gupta, Amitabha; Sharma, Sushma; Reichenbach, Patrick; et al.

Replication fork collapse and genome instability in dCMP deaminase mutant

Molecular and Cellular Biology, Washington: American Society Microbiology 2012, Vol. 32, (21) : 4445-4454

Sánchez, Arancha; Sharma, Sushma; Rozenzhak, Sophie; et al.

Imbalanced dNTP pools induce mutator and cancer phenotypes in mice

Tran, Phong; Moskalenko, Roman; Sharma, Sushma; et al.

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Research groups

Group member

Andrei Chabes Lab