Simon Tuck

Research qualifications: Docent

Contact

simon.tuck@umu.se

+46 90 786 67 87

Works as

Professor at Department of Medical and Translational Biology Section: Section for Molecular Medicine

hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Homepage

Halymenia durvillei extracts exert antiobesity effects by targeting hosl-1-mediated lipolysis in a glucose-induced caenorhabditis elegans model

eFood, John Wiley & Sons 2025, Vol. 6, (3)

Chumphoochai, Kawita; Promtang, Sukrit; Chalorak, Pawanrat; et al.

Shaker/Kv1 potassium channel SHK-1 protects against pathogen infection and oxidative stress in C. elegans

PLOS Genetics, Public Library of Science (PLoS) 2025, Vol. 21, (2)

Pu, Longjun; Wang, Jing; Nilsson, Lars; et al.

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

Communications Biology, Springer Nature 2021, Vol. 4, (1)

Herdenberg, Carl; Mutie, Pascal; Billing, Ola; et al.

C. elegans TAT-6, a putative aminophospholipid translocase, is expressed in sujc cells in the hermaphrodite gonad

microPublication biology

Nilsson, Lars; Rahmani, Shapour; Tuck, Simon

EGL-4 promotes turning behavior of C. elegans males during mating

microPublication biology

Rahmani, Shapour; Tuck, Simon

Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems

Molecular Nutrition & Food Research, WILEY 2019, Vol. 63, (9)

Rohn, Isabelle; Raschke, Stefanie; Aschner, Michael; et al.

Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts

Communications Biology, Springer Nature Publishing AG 2018, Vol. 1

Dongre, Mitesh; Singh, Bhupender; Aung, Kyaw Min; et al.

Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans

Metallomics, Royal Society of Chemistry 2018, Vol. 10, (6) : 818-827

Rohn, Isabelle; Marschall, Talke Anu; Kroepfl, Nina; et al.

Mutations in the Caenorhabditis elegans orthologs of human genes required for mitochondrial tRNA modification cause similar electron transport chain defects but different nuclear responses

PLOS Genetics, Vol. 13, (7)

Navarro-Gonzalez, Carmen; Moukadiri, Ismail; Villarroya, Magda; et al.

Fourier transform infrared microspectroscopy for the analysis of the biochemical composition of C. elegans worms

Worm, Taylor & Francis 2016, Vol. 5, (1)

Sheng, Ming; Gorzsás, András; Tuck, Simon

Aberrant Fat Metabolism in Caenorhabditis elegans Mutants with Defects in the Defecation Motor Program

PLOS ONE, PLOS one 2015, Vol. 10, (4)

Sheng, Ming; Hosseinzadeh, Ava; Muralidharan, Somsundar Veppil; et al.

The control of cell growth and body size in Caenorhabditis elegans

Experimental Cell Research, Vol. 321, (1) : 71-76

Tuck, Simon

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.

Development, Vol. 139, (5) : 859-870

Korta, Dorota Z; Tuck, Simon; Hubbard, E Jane Albert

Tissue- and paralogue-specific functions of acyl-CoA-binding proteins in lipid metabolism in Caenorhabditis elegans

Biochemical Journal, Vol. 437, (2) : 231-241

Elle, Ida C; Simonsen, Karina T; Olsen, Louise C B; et al.

Caenorhabditis elegans Numb Inhibits Endocytic Recycling by Binding TAT-1 Aminophospholipid Translocase

Traffic: the International Journal of Intracellular Transport, Malden: Wiley-Blackwell 2011, Vol. 12, (12) : 1839-1849

Nilsson, Lars; Jonsson, Eva; Tuck, Simon

Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans

Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, (3) : 1064-1069

Stenvall, Jörgen; Fierro-González, Juan Carlos; Swoboda, Peter; et al.

Extracellular vesicles: budding regulated by a phosphatidylethanolamine translocase

Current Biology, Vol. 21, (24) : R988-R990

Tuck, Simon

TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans

Molecular Biology of the Cell, American Society for Cell Biology 2010, Vol. 21, (13) : 2285-2296

Chotard, Laëtitia; Mishra, Ashwini K; Sylvain, Marc-André; et al.

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants

PLoS genetics, Vol. 5, (7) : e1000561-

Chen, Changchun; Tuck, Simon; Byström, Anders S

The C. elegans P4-ATPase TAT-1 regulates Lysosome Biogenesis and Endocytosis

Traffic: the International Journal of Intracellular Transport, Vol. 10, (1) : 88-100

Ruaud, Anne-Françoise; Nilsson, Lars; Richard, Fabrice; et al.

Caenorhabditis elegans num-1 negatively regulates endocytic recycling

Genetics, Vol. 179 : 375-387

Nilsson, Lars; Conradt, Barbara; Ruaud, Anne-Françoise; et al.

Diet-dependent depletion of queuosine in tRNAs in Caenorhabditis elegans does not lead to a developmental block.

J Biosci, Vol. 32, (4) : 747-54

Gaur, Rahul; Björk, Glenn; Tuck, Simon; et al.

ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.

Cell, Vol. 128, (3) : 577-87

Kao, Gautam; Nordenson, Cecilia; Still, Maria; et al.

MAA-1, a novel acyl-CoA-binding protein involved in endosomal vesicle transport in Caenorhabditis elegans.

Mol Biol Cell, Vol. 17, (10) : 4318-29

Larsen, Morten K; Tuck, Simon; Faergeman, Nils J; et al.

A Vibrio cholerae protease needed for killing of Caenorhabditis elegans has a role in protection from natural predator grazing

Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, (24) : 9280-9285

Vaitkevicius, Karolis; Lindmark, Barbro; Ou, Gangwei; et al.

A Caenorhabditis elegans mutant lacking functional nicotinamide nucleotide transhydrogenase displays increased sensitivity to oxidative stress.

Free Radic Biol Med, Vol. 38, (11) : 1518-25

Arkblad, Eva L; Tuck, Simon; Pestov, Nikolay B; et al.

Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.

Proc Natl Acad Sci U S A, Vol. 102, (33) : 11757-62

Rocheleau, Christian E; Rönnlund, Agneta; Tuck, Simon; et al.

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.

Cell Death Differ, Vol. 12, (2) : 153-61

Schumacher, B; Schertel, C; Wittenburg, N; et al.

lin-1 has both positive and negative functions in specifying multiple cell fates induced by Ras/MAP kinase signaling in C. elegans.

Dev Biol, Vol. 286, (1) : 338-51

Tiensuu, Teresa; Larsen, Morten Krog; Vernersson, Emma; et al.

C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites

Development, Cambridge: Company of Biologists Limited 2004, Vol. 131, (4) : 755-765

Kao, Gautam; Tuck, Simon; Baillie, David; et al.

Stress response in Caenorhabditis elegans caused by optical tweezers: wavelength, power, and time dependence

Biophysical Journal, Biophysical Society 2002, Vol. 82, (4) : 2224-2231

Leitz, Guenther; Fällman, Erik; Tuck, Simon; et al.

Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length.

Genetics, Vol. 161, (1) : 83-97

Nyström, Josefin; Shen, Zai-Zhong; Aili, Margareta; et al.

EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.

Mol Biol Cell, Vol. 11, (4) : 1401-19

Furuta, T; Tuck, S; Kirchner, J; et al.

Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains.

Genetics, Vol. 156, (3) : 1083-96

Nilsson, L; Tiensuu, T; Tuck, S

A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting.

Development, Vol. 126, (3) : 597-606

Yochem, J; Tuck, S; Greenwald, I; et al.

Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.

Development, Vol. 125, (23) : 4809-19

Nilsson, L; Li, X; Tiensuu, T; et al.

TAT-5 and TAT-6 P4-family ATPases regulate the release of extracellular vesicles containing polycystins from Caenorhabditis elegans sensilla

Nilsson, Lars; Rahmani, Shapour; Hubert, Madlen; et al.

Increased release of extracellular vesicles from C. elegans sensilla in mutants with lysosomal defects

Rahmani, Shapour; Tuck, Simon

Activation of cGMP signalling inhibits response behaviour of C. elegans males during mating

Rahmani, Shapour; Tuck, Simon

View publications in DiVA

Research groups

Head of research

Simon Tuck lab