Robin Fåhraeus

Contact

robin.fahraeus@umu.se

Works as

Professor at Department of Medical Biosciences

By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå

The p53 mRNA exhibits riboswitch-like features under DNA damage conditions

iScience, Elsevier 2025, Vol. 28, (10)

Chen, Sa; Wang, Lixiao; Malbert-Colas, Laurence; et al.

Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA

Bioscience Reports, Portland Press 2025, Vol. 45, (11) : 683-696

Kucerikova, Martina; Bonczek, Ondrej; Olivares-Illana, Vanesa; et al.

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

British Journal of Cancer, Springer Nature 2025, Vol. 133 : 970-975

Sajwan, Rhythm; Wang, Lixiao; Casar-Borota, Olivera; et al.

The codon context provides cis-acting immune evasion for the human papilloma virus (HPV) E6

RNA: A publication of the RNA Society, Cold Spring Harbor Laboratory Press (CSHL) 2025, Vol. 31, (12) : 1735-1748

Thermou, Aikaterini; Daskalogianni, Chrysoula; Wang, Lixiao; et al.

Translation of bi-directional transcripts enhances MHC-I peptide diversity

Frontiers in Immunology, Frontiers Media S.A. 2025, Vol. 16

Zavadil, Filip; Henek, Tomas; Habault, Justine; et al.

Has translation in the nucleus found its purpose?

Nature reviews. Molecular cell biology, Springer Nature 2024, Vol. 25, (1) : 1-2

Fåhraeus, Robin

The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway

Molecular Cancer, Springer Nature 2024, Vol. 23, (1)

Karakostis, Konstantinos; Malbert-Colas, Laurence; Thermou, Aikaterini; et al.

Thermal stress, p53 structures and learning from elephants

Cell Death Discovery, Springer Nature 2024, Vol. 10, (1)

Karakostis, Konstantinos; Padariya, Monikaben; Thermou, Aikaterini; et al.

Re-appraising the evidence for the source, regulation and function of p53-family isoforms

Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (20) : 12112-12129

López, Ignacio; Valdivia, Irene Larghero; Vojtesek, Borivoj; et al.

In search of the cell biology for self- versus non-self- recognition

Current Opinion in Immunology, Vol. 83

Apcher, Sebastien; Vojtesek, Borek; Fåhraeus, Robin

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Cell Death and Differentiation, Springer Nature 2023, Vol. 30 : 1072-1081

Fusée, Leila; Salomao, Norman; Ponnuswamy, Anand; et al.

Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia

British Journal of Haematology, John Wiley & Sons 2023, Vol. 201, (2) : 234-248

Salomao, Norman; Maslah, Nabih; Giulianelli, Anouk; et al.

Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2023, Vol. 120, (7)

Sroka, Ewa Maria; Lavigne, Mathilde; Pla, Marika; et al.

mRNA translation from an antigen presentation perspective: A tribute to the works of Nilabh Shastri

Molecular Immunology, Elsevier 2022, Vol. 141 : 305-308

Apcher, Sebastien; Tovar-Fernadez, Maria; Ducellier, Sarah; et al.

Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism

Bioscience Reports, Portland Press 2022, Vol. 42, (7)

Calderon-González, Karla Gisel; Medina-Medina, Ixaura; Haronikova, Lucia; et al.

Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets

Cancers, MDPI 2022, Vol. 14, (3)

Karagiannakos, Alexandros; Adamaki, Maria; Tsintarakis, Antonis; et al.

The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer

Molecular biology and evolution, Oxford University Press 2022, Vol. 39, (7)

Padariya, Monikaben; Jooste, Mia-Lyn; Hupp, Ted; et al.

Substrate-specific presentation of MHC class I-restricted antigens via autophagy pathway

Cellular Immunology, Elsevier 2022, Vol. 374

Tovar Fernandez, Maria C.; Sroka, Ewa M.; Lavigne, Mathilde; et al.

The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA

Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (17) : 10110-10122

Zheng, Alice J L; Thermou, Aikaterini; Daskalogianni, Chrysoula; et al.

The different activities of RNA G-quadruplex structures are controlled by flanking sequences

Life Science Alliance, Rockefeller University Press 2022, Vol. 5, (2)

Zheng, Alice J.-L.; Thermou, Aikaterini; Gallardo, Pedro Guixens; et al.

Low potential of circulating interleukin 1 receptor antagonist as a prediction marker for squamous cell carcinoma of the head and neck

Journal of Oral Pathology & Medicine, John Wiley & Sons 2021, Vol. 50, (8) : 785-794

Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.

P53 mRNA metabolism links with the DNA damage response

Genes, MDPI 2021, Vol. 12, (9)

Gnanasundram, Sivakumar Vadivel; Bonczek, Ondrej; Wang, Lixiao; et al.

Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?

Cellular & Molecular Biology Letters (Druk), BioMed Central 2021, Vol. 26, (1)

Haronikova, Lucia; Bonczek, Ondrej; Zatloukalova, Pavlina; et al.

Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms

Biomolecules, MDPI 2021, Vol. 11, (1)

Karakostis, Konstantinos; Lopez, Ignacio; Pena-Balderas, Ana M.; et al.

Identification of a stable, non-canonically regulated nrf2 form in lung cancer cells

Antioxidants, MDPI 2021, Vol. 10, (5)

Mikac, Sara; Rychłowski, Michał; Dziadosz, Alicja; et al.

Molecular determinants and specificity of mrna with alternatively-spliced upf1 isoforms, influenced by an insertion in the 'regulatory loop'

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (23)

Padariya, Monikaben; Fåhraeus, Robin; Hupp, Ted; et al.

Viruses, cancer and non-self recognition

Open Biology, The Royal Society 2021, Vol. 11, (3)

Padariya, Monikaben; Kalathiya, Umesh; Mikac, Sara; et al.

Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations

Computational and Structural Biotechnology Journal, Elsevier 2021, Vol. 19 : 5072-5091

Padariya, Monikaben; Kote, Sachin; Mayordomo, Marcos; et al.

Functional interfaces, biological pathways, and regulations of interferon-related dna damage resistance signature (Irds) genes

Biomolecules, MDPI 2021, Vol. 11, (5)

Padariya, Monikaben; Sznarkowska, Alicja; Kote, Sachin; et al.

What do we need to know and understand about p53 to improve its clinical value?

Journal of Pathology, John Wiley & Sons 2021, Vol. 254, (4) : 443-453

Salomao, Norman; Karakostis, Konstantinos; Hupp, Ted; et al.

Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck

Oncology Letters, Spandidos Publications 2020, Vol. 20, (2) : 1709-1718

Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.

Alternative Mechanisms of p53 Action During the Unfolded Protein Response

Cancers, Vol. 12, (2)

Fusee, Leila T. S.; Marin, Monica; Fåhraeus, Robin; et al.

MDM2's dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities

Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (12) : 6775-6787

Gnanasundram, Sivakumar Vadivel; Malbert-Colas, Laurence; Chen, Sa; et al.

Transfer-RNA-Derived Fragments Are Potential Prognostic Factors in Patients with Squamous Cell Carcinoma of the Head and Neck

Genes, MDPI 2020, Vol. 11, (11)

Gu, Xiaolian; Wang, Lixiao; Coates, Philip J.; et al.

PD-L1 in squamous cell carcinoma of the oral tongue shows gender-specific association with prognosis

Oral Diseases, John Wiley & Sons 2020, Vol. 26, (7) : 1414-1423

Wilms, Torben; Gu, Xiaolian; Boldrup, Linda; et al.

High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

The journal of pathology. Clinical research, John Wiley & Sons 2019, Vol. 5, (4) : 240-247

Gu, Xiaolian; Boldrup, Linda; Coates, Philip J.; et al.

Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue

Journal of Oral Pathology & Medicine, John Wiley & Sons 2019, Vol. 48, (1) : 24-30

Gu, Xiaolian; Coates, Philip J.; Boldrup, Linda; et al.

AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck

Cancers, MDPI 2019, Vol. 11, (3)

Gu, Xiaolian; Wang, Lixiao; Boldrup, Linda; et al.

The p53 mRNA: an integral part of the cellular stress response

Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (7) : 3257-3271

Haronikova, Lucia; Olivares-Illana, Vanesa; Wang, Lixiao; et al.

Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signatures

BMC Cancer, BioMed Central 2019, Vol. 19, (1)

Karakostis, Konstantinos; Fåhraeus, Robin

A single synonymous mutation determines the phosphorylation and stability of the nascent protein

Journal of Molecular Cell Biology, Oxford University Press 2019, Vol. 11, (3) : 187-199

Karakostis, Konstantinos; Gnanasundram, Sivakumar Vadivel; Lopez, Ignacio; et al.

Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides

Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (6) : 3086-3100

Martins, Rodrigo Prado; Malbert-Colas, Laurence; Lista, Maria Jose; et al.

Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function

Biochemical Journal, PORTLAND PRESS LTD 2019, Vol. 476 : 3401-3411

Uhrik, Lukas; Wang, Lixiao; Haronikova, Lucia; et al.

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

Frontiers in Immunology, Frontiers Media S.A. 2019, Vol. 10

Urban-Wojciuk, Zuzanna; Khan, Mohd M.; Oyler, Benjamin L.; et al.

Peptide Channeling: The Key to MHC Class I Immunosurveillance?

Trends in Cell Biolology, Elsevier 2019, Vol. 29, (12) : 929-939

Yewdell, Jonathan W.; Dersh, Devin; Fåhraeus, Robin

Translation Stress Regulates Ribosome Synthesis and Cell Proliferation

International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (12)

Gnanasundram, Sivakumar Vadivel; Fåhraeus, Robin

In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules

Molecules, MDPI 2018, Vol. 23, (12)

Martins, Rodrigo Prado; Findakly, Sarah; Daskalogianni, Chrysoula; et al.

Searching for new targets and treatments in the battle against squamous cell carcinoma of the head and neck, with specific focus on tumours of the tongue

Current Topics in Medicinal Chemistry, Bentham Science Publishers 2018, Vol. 18, (3) : 214-218

Sgaramella, Nicola; Gu, Xiaolian; Boldrup, Linda; et al.

Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue

Oncology Letters, Spandidos Publications 2018, Vol. 16, (5) : 6603-6607

Sgaramella, Nicola; Wilms, Torben; Boldrup, Linda; et al.

Gene expression changes in tumor free tongue tissue adjacent to tongue squamous cell carcinoma

Oncotarget, Vol. 8, (12) : 19389-19402

Boldrup, Linda; Gu, Xiaolian; Coates, Philip J.; et al.

View publications in DiVA

Research groups

Head of research

Robin Fåhraeus Lab