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Staff photo Peter Andersen
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Peter Andersen

Professor and senior Consultant Neurologist. Since 1992 my research focus on the etiology of ALS/FTD and testing new experimental medicines for treating ALS.

Research qualifications: Docent
0000-0003-0094-5429

Contact

E-mail
peter.andersen@umu.se
Phone
+46 70 647 69 13

Works as

Affiliation
Professor, senior consultant (attending) physician at Department of Clinical Sciences Section: Neurosciences
Location
Norrlands universitetssjukhus, Umeå universitet, Klinisk vetenskap Umeå universitet, Klinisk vetenskap, 901 85 Umeå
Landscapes of missense variant impact for human superoxide dismutase 1
American Journal of Human Genetics, Elsevier 2025, Vol. 112, (10) : 2295-2315
Axakova, Anna; Ding, Megan; Cote, Atina G.; et al.
Proposed research criteria for mild motor impairment as a prodromal syndrome in amyotrophic lateral sclerosis
Neurology, Wolters Kluwer 2025, Vol. 105, (4)
Benatar, Michael; Cai, Xueya; McDermott, Michael P.; et al.
Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention
Lancet Neurology, Elsevier 2025, Vol. 24, (1) : 77-86
Benatar, Michael; Robertson, Janice; Andersen, Peter Munch
Phenotypic characterization of ALS-causing SOD1 mutations affecting polypeptide length
Human Mutation, John Wiley & Sons 2025, Vol. 2025, (1)
Berdyński, Mariusz; Safranow, Krzysztof; Andersen, Peter M.; et al.
Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2025, Vol. 96, (10) : 928-936
Iacoangeli, Alfredo; Dilliott, Allison A.; Al Khleifat, Ahmad; et al.
A comparison of p-tau assays for the specificity to detect tau changes in Alzheimer's disease
Alzheimer's & Dementia: Journal of the Alzheimer's Association, John Wiley & Sons 2025, Vol. 21, (4)
Janelidze, Shorena; Ashton, Nicholas J.; Orduña Dolado, Anna; et al.
SOD1 protein content in human central nervous system and peripheral tissues
Journal of Neurochemistry, John Wiley & Sons 2025, Vol. 169, (6)
Leykam, Laura; Jonsson, Andreas P.; Forsberg, Karin M. E.; et al.
Transformed parenthood in the face of ALS: a profound struggle for both ill parents and co-parents
Global Qualitative Nursing Research, Sage Publications 2025, Vol. 12
Malmström, Nina; Öhlén, Joakim; Nilsson, Stefan; et al.
Diverse effects of coexpression of human SOD1 variants on motor neuron disease
Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (16) : 1380-1391
Tokuda, Eiichi; Leykam, Laura; Zetterström, Per; et al.
Identification of a presymptomatic and early disease signature for amyotrophic lateral sclerosis (ALS): protocol of the premodiALS study
Neurological Research and Practice, BioMed Central (BMC) 2025, Vol. 7, (1)
Tzeplaeff, Laura; Galhoz, Ana; Meijs, Clara; et al.
Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
Lancet Neurology, Elsevier 2024, Vol. 23, (7) : 687-699
Benatar, Michael; Hansen, Thomas; Rom, Dror; et al.
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Nature Reviews Neurology, Springer Nature 2024, Vol. 20, (6) : 364-376
Benatar, Michael; Wuu, Joanne; Huey, Edward D.; et al.
Upregulated miR-10b-5p as a potential miRNA signature in amyotrophic lateral sclerosis patients
Frontiers in Cellular Neuroscience, Frontiers Media S.A. 2024, Vol. 18
Dash, Banaja P.; Freischmidt, Axel; Helferich, Anika M.; et al.
Precisionsmedicinsk genterapi har bromsat utveckling av ALS: [SOD1 gene therapy delays ALS disease progression]
Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121
Forsberg, Karin; Karlsborg, Merete; Salvesen, Lisette; et al.
Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations
Neurobiology of Disease, Elsevier 2024, Vol. 202
Leykam, Laura; Forsberg, Karin; Nordström, Ulrika; et al.
Adolescents' challenging and grief-filled transitions when living with a parent with ALS: a qualitative interpretive study
Social Science and Medicine, Elsevier 2024, Vol. 354
Malmström, Nina; Öhlén, Joakim; Jakobsson Larsson, Birgitta; et al.
Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS
Annals of Clinical and Translational Neurology, John Wiley & Sons 2024, Vol. 11, (7) : 1775-1786
Marriott, Heather; Spargo, Thomas P.; Al Khleifat, Ahmad; et al.
Small striatal huntingtin inclusions in patients with motor neuron disease with reduced penetrance and intermediate HTT gene expansions
Human Molecular Genetics, Oxford University Press 2024, Vol. 33, (22) : 1966-1974
Roos, Anna-Karin; Stenvall, Erica; Kockum, Emmy Skelton; et al.
High levels of neurofilament light and YKL-40 in cerebrospinal fluid are related to poor outcome in ALS
Journal of the Neurological Sciences, Elsevier 2024, Vol. 463
Rosén, Christoffer; Mitre, Bernardo; Nellgård, Bengt; et al.
European academy of neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European reference network for neuromuscular diseases (ERN EURO-NMD)
European Journal of Neurology, John Wiley & Sons 2024, Vol. 31, (6)
Van Damme, Philip; Al-Chalabi, Ammar; Andersen, Peter M.; et al.
Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients
Communications Medicine, Springer Nature 2024, Vol. 4, (1)
Weishaupt, Jochen H.; Körtvélyessy, Péter; Schumann, Peggy; et al.
Cognitive deficits in ALS patients with SOD1 mutations
Journal of Clinical and Experimental Neuropsychology, Routledge 2024, Vol. 46, (7) : 669-682
Winroth, Ivar; Börjesson, Arne; Andersen, Peter M.; et al.
Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival
Frontiers in Cellular Neuroscience, Frontiers Media S.A. 2023, Vol. 17
Adey, Brett N.; Cooper-Knock, Johnathan; Al Khleifat, Ahmad; et al.
Myofiber type shift in extraocular muscles in amyotrophic lateral sclerosis
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2023, Vol. 64, (5)
Behzadi, Arvin; Tjust, Anton Erik; Liu, Jing-Xia; et al.
Quality of life and depression in patients with amyotrophic lateral sclerosis – does the country of origin matter?
BMC Palliative Care, BioMed Central (BMC) 2023, Vol. 22, (1)
Ciećwierska, Katarzyna; Lulé, Dorothée; Bielecki, Maksymilian; et al.
Clinical testing panels for ALS: global distribution, consistency, and challenges
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 420-435
Dilliott, Allison A.; Al Nasser, Ahmad; Elnagheeb, Marwa; et al.
Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriers
EBioMedicine, Elsevier 2023, Vol. 90
Dorst, Johannes; Weydt, Patrick; Brenner, David; et al.
A novel homozygous p.Ser69Pro SOD1 mutation causes severe young-onset ALS with decreased enzyme activity
Journal of Neurology, Springer 2023, Vol. 270 : 1770-1773
Fahmy, Nagia; Müller, Kathrin; Andersen, Peter Munch; et al.
Determining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 475-484
Finsel, Julia; Winroth, Ivar; Ciećwierska, Katarzyna; et al.
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.
Validity and reliability measures of the Swedish Karolinska version of the Edinburgh Cognitive and Behavioral ALS Screen (SK-ECAS)
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (7-8) : 713-718
Foucher, Juliette; Winroth, Ivar; Lovik, Anikó; et al.
Living with a parent with ALS - adolescents' need for professional support from the adolescents' and the parents' perspectives
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (7-8) : 727-735
Malmström, Nina; Jakobsson Larsson, Birgitta; Nilsson, Stefan; et al.
Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Nature Communications, Nature Publishing Group 2023, Vol. 14, (1)
Megat, Salim; Mora, Natalia; Sanogo, Jason; et al.
Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS
Journal of Neurochemistry, John Wiley & Sons 2023, Vol. 164, (1) : 77-93
Nordström, Ulrika; Lang, Lisa; Ekhtiari Bidhendi, Elaheh; et al.
The motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1
Brain Communications, Oxford University Press 2023, Vol. 5, (1)
Park, Julien H.; Nordström, Ulrika; Tsiakas, Konstantinos; et al.
Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis
Neurobiology of Aging, Elsevier 2023, Vol. 122 : 76-87
Tazelaar, Gijs H.P.; Hop, Paul J.; Seelen, Meinie; et al.
Genetic variability in sporadic amyotrophic lateral sclerosis
Brain, Oxford University Press 2023, Vol. 146, (9) : 3760-3769
Van Daele, Sien Hilde; Moisse, Matthieu; van Vugt, Joke J F A; et al.
Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 414-419
Yilmaz, Rüstem; Grehl, Torsten; Eckrich, Lukas; et al.
Live cell imaging of ATP levels reveals metabolic compartmentalization within motoneurons and early metabolic changes in FUS ALS motoneurons
Cells, MDPI 2023, Vol. 12, (10)
Zimyanin, Vitaly L.; Pielka, Anna-Maria; Glaß, Hannes; et al.
Caregivers’ divergent perspectives on patients’ well-being and attitudes towards hastened death in Germany, Poland and Sweden
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2022, Vol. 23, (3-4) : 252-262
Andersen, Peter M.; Kuźma-Kozakiewicz, Magdalena; Keller, Jürgen; et al.
Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity
Brain, Oxford University Press 2022, Vol. 145, (10) : 3500-3508
Benatar, Michael; Granit, Volkan; Andersen, Peter M.; et al.
Design of a randomized, placebo-controlled, phase 3 trial of tofersen initiated in clinically presymptomatic SOD1 variant carriers: the Atlas study
Neurotherapeutics, Springer 2022, Vol. 19 : 1248-1258
Benatar, Michael; Wuu, Joanne; Andersen, Peter M.; et al.
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
Brain, Oxford University Press 2022, Vol. 145, (1) : 27-44
Benatar, Michael; Wuu, Joanne; McHutchison, Caroline; et al.
SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity
Scientific Reports, Nature Publishing Group 2022, Vol. 12, (1)
Berdynski, Mariusz; Miszta, Przemysław; Safranow, Krzysztof; et al.
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
Neurogenetics, Springer 2022, Vol. 23 : 59-65
Brenner, David; Müller, Kathrin; Lattante, Serena; et al.
Infantile SOD1 deficiency syndrome caused by a homozygous SOD1 variant with absence of enzyme activity
Brain, Oxford University Press 2022, Vol. 145, (3) : 872-878
Ezer, Shlomit; Daana, Muhannad; Park, Julien H.; et al.
Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS
Cells, MDPI 2022, Vol. 11, (7)
Günther, René; Pal, Arun; Williams, Chloe; et al.
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Science Translational Medicine, American Association for the Advancement of Science 2022, Vol. 14, (633)
Hop, Paul J.; Zwamborn, Ramona A.J.; Hannon, Eilis; et al.
Clinical trials in pediatric ALS: a TRICALS feasibility study
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis Group 2022, Vol. 23, (7-8) : 481-488
Kliest, Tessa; Van Eijk, Ruben P.A.; Al-Chalabi, Ammar; et al.
Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
European Journal of Neurology, John Wiley & Sons 2022, Vol. 29, (4) : 1279-1283
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; et al.
View publications in DiVA

Since 1999 I teach the medical students at Umeå University, terms 9 and 10.

Learning about protein aggregates to solve the riddle of ALS

Peter Andersen has found mechanisms that may make it possible to treat or even prevent it.