Per-Arne Oldenborg

Contact

per-arne.oldenborg@umu.se

+46 90 786 59 74, +46 70 337 59 74

Works as

Professor at Department of Medical and Translational Biology Section: Administration IMB, Group Per-Arne Oldenborg

Umeå universitet, 901 87 Umeå

The expression of signal regulatory protein alpha (SIRPα) in periodontal cells and tissue

Acta Odontologica Scandinavica, Medical Journals Sweden 2024, Vol. 83 : 486-492

Koskinen Holm, Cecilia; Rosendahl, Sara; Oldenborg, Per-Arne; et al.

Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells

Cell Communication and Signaling, Springer Nature 2020, Vol. 18, (1)

Bissinger, Rosi; Petkova-Kirova, Polina; Mykhailova, Olga; et al.

In vitro phagocytosis of liquid-stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate

Vox Sanguinis, John Wiley & Sons 2020, Vol. 115, (8) : 647-654

Hult, Andreas; Toss, Fredrik; Malm, Christer B.; et al.

Microglial SIRP alpha regulates the emergence of CD11c(+) microglia and demyelination damage in white matter

eLIFE, eLIFE Sciences Publications 2019, Vol. 8

Sato-Hashimoto, Miho; Nozu, Tomomi; Toriba, Riho; et al.

Anti-human SIRP antibody is a new tool for cancer immunotherapy

Cancer Science, WILEY 2018, Vol. 109, (5) : 1300-1308

Murata, Yoji; Tanaka, Daisuke; Hazama, Daisuke; et al.

Human and murine splenic neutrophils are potent phagocytes of IgG-opsonized red blood cells

Blood Advances, American Society of Hematology 2017, Vol. 1, (14) : 875-886

Meinderts, Sanne M.; Oldenborg, Per-Arne; Beuger, Boukje M.; et al.

Eryptosis in health and disease: A paradigm shift towards understanding the (patho)physiological implications of programmed cell death of erythrocytes

Blood reviews, CHURCHILL LIVINGSTONE 2017, Vol. 31, (6) : 349-361

Qadri, Syed M.; Bissinger, Rosi; Solh, Ziad; et al.

Anti-SIRP alpha antibodies as a potential new tool for cancer immunotherapy

JCI Insight, American Society for Clinical Investigation 2017, Vol. 2, (1)

Yanagita, Tadahiko; Murata, Yoji; Tanaka, Daisuke; et al.

Lack of SIRP alpha phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation

Biochemical and Biophysical Research Communications - BBRC, Vol. 478, (1) : 268-273

Holm, Cecilia Koskinen; Engman, Sara; Sulniute, Rima; et al.

Red blood cells with elevated cytoplasmic Ca2+ are primarily taken up by splenic marginal zone macrophages and CD207+dendritic cells

Transfusion, Vol. 56, (7) : 1834-1844

Larsson, Anders; Hult, Andreas; Nilsson, Anna; et al.

Antibody-mediated phagocytosis of red blood cells by neutrophils in the human spleen

European Journal of Clinical Investigation, Vol. 46 : 77-77

Meinderts, S. M.; Oldenborg, Per-Arne; Beuger, B.; et al.

Lack of non-hematopoietic SIRPα signaling disturbs the splenic marginal zone architecture resulting in accumulation and displacement of marginal zone B cells

Biochemical and Biophysical Research Communications - BBRC, Vol. 460, (3) : 645-650

Kolan, Shrikant; Boman, Andreas; Matozaki, Takashi; et al.

Non-Hematopoietic and Hematopoietic SIRPα Signaling Differently Regulates Murine B Cell Maturation in Bone Marrow and Spleen

PLoS One, plos one 2015, Vol. 10, (7)

Kolan, Shrikant; Lejon, Kristina; Koskinen Holm, Cecilia; et al.

Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation

Journal of Innate Immunity, Vol. 6, (4) : 553-560

Stenberg, Åsa; Karlsson, Anna; Feuk-Lagerstedt, Elisabeth; et al.

Macrophages: Good guys in colorectal cancer

Oncoimmunology, Vol. 2, (2) : e23038-

Edin, Sofia; Wikberg, Maria L; Oldenborg, Per-Arne; et al.

Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells

PLOS ONE, PLoS, Public Library of Science 2013, Vol. 8, (9) : e74982-

Edin, Sofia; Wikberg, Maria L; Rutegård, Jörgen; et al.

Transfusion of cryopreserved human red blood cells into healthy humans is associated with rapid extravascular hemolysis without a proinflammatory cytokine response

Transfusion, John Wiley & Sons 2013, Vol. 53, (1) : 28-33

Hult, Andreas; Malm, Christer; Oldenborg, Per-Arne

Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein α (SIRPα) signaling

Journal of Biological Chemistry, Vol. 288, (41) : 29333-29344

Koskinen, Cecilia; Persson, Emelie; Baldock, Paul; et al.

CD47: a cell surface glycoprotein which regulates multiple functions of hematopoietic cells in health and disease.

ISRN Hematology, Vol. 2013 : 614619-

Oldenborg, Per-Arne

Neutrophil apoptosis is associated with loss of signal regulatory protein alpha (SIRP alpha) from the cell surface

Journal of Leukocyte Biology, Vol. 93, (3) : 403-412

Stenberg, Åsa; Sehlin, Janove; Oldenborg, Per-Arne

The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer

PLOS ONE, PLoS One 2012, Vol. 7, (10) : e47045-

Edin, Sofia; Wikberg, Maria L.; Dahlin, Anna M.; et al.

Lack of CD47 leads to impaired bone cell differentiation and results in an osteopenic bone phenotype

Bone, Vol. 50, (Supplement 1) : S42-S43

Koskinen, Cecilia; Persson, Emma; Baldock, P.; et al.

The absence of CD47 promotes nerve fiber growth from cultured ventral mesencephalic dopamine neurons

PLOS ONE, Public library of science 2012, Vol. 7, (9) : e45218-

Marschinke, Franziska; Hashemian, Sanaz Alsadat; Matozaki, Takashi; et al.

Hypothermia-induced tyrosine phosphorylation of SIRPα in the brain

Journal of Neurochemistry, John Wiley & Sons 2012, Vol. 121, (6) : 891-902

Maruyama, Toshi; Kusakari, Shinya; Sato-Hashimoto, Miho; et al.

Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids

Biochemical and Biophysical Research Communications - BBRC, San Diego: Elsevier 2012, Vol. 417, (4) : 1304-1309

Nilsson, Anna; Vesterlund, Liselotte; Oldenborg, Per-Arne

Role of CD47 and Signal Regulatory Protein Alpha (SIRP alpha) in Regulating the Clearance of Viable or Aged Blood Cells

Transfusion Medicine and Hemotherapy, Vol. 39, (5) : 315-320

Oldenborg, Per-Arne

CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a maintained capacity to induce oral tolerance

Immunology, Malden: Wiley-Blackwell 2012, Vol. 135, (3) : 236-244

Westlund, Jessica; Livingston, Megan; Fahlen-Yrlid, Linda; et al.

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPalpha (signal regulatory protein-alpha) on phagocytes

Journal of Neuroinflammation, Vol. 8, (1) : 24-

Gitik, Miri; Liraz Zaltsman, Sigal; Oldenborg, Per-Arne; et al.

Blocking cd47/ox101 makes the astrocytes permissive for nerve fiber growth

Glia: 10th European meeting on Glial Cells in Health and Disease, New York, N.Y.: Wiley-Liss, Inc. 2011 : S105-S106

Hashemian, Sanaz Alsadat; Marschinke, Franziska; Oldenborg, Per-Arne; et al.

Colorectal Cancer Cells Activate Adjacent Fibroblasts Resulting in FGF1/FGFR3 Signaling and Increased Invasion.

American Journal of Pathology, Elsevier 2011, Vol. 178, (3) : 1387-1394

Henriksson, Maria L; Edin, Sofia; Dahlin, Anna M; et al.

Signal regulatory protein α regulates the homeostasis of T lymphocytes in the spleen.

Journal of Immunology, American Association of Immunologists 2011, Vol. 187, (1) : 291-297

Sato-Hashimoto, Miho; Saito, Yasuyuki; Ohnishi, Hiroshi; et al.

Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test

Journal of Neuroscience, Vol. 30, (31) : 10472-10483

Ohnishi, Hiroshi; Murata, Takaaki; Kusakari, Shinya; et al.

Regulation by SIRPα of dendritic cell homeostasis in lymphoid tissues

Blood, Vol. 116, (18) : 3517-3525

Saito, Yasuyuki; Iwamura, Hiroko; Kaneko, Tetsuya; et al.

CD47 is required for suppression of allograft rejection by donor-specific transfusion

Journal of Immunology, Vol. 184, (7) : 3401-3407

Wang, Hui; Wu, Xiaojian; Wang, Yuantao; et al.

CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration.

PloS one, Vol. 4, (7) : e6371-

Broom, Oliver Jay; Zhang, Yuan; Oldenborg, Per-Arne; et al.

CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages

Biochemical and Biophysical Research Communications - BBRC, Elsevier 2009, Vol. 387, (1) : 58-63

Nilsson, Anna; Oldenborg, Per-Arne

Essential roles of SHPS-1 in induction of contact hypersensitivity of skin.

Immunology Letters, Vol. 121, (1) : 52-60

Motegi, Sei-Ichiro; Okazawa, Hideki; Murata, Yoji; et al.

CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages.

Blood, Vol. 112, (10) : 4259-67

Olsson, Mattias; Oldenborg, Per-Arne

Osteoclast formation is strongly reduced both in vivo and in vitro in the absence of CD47/SIRPalpha-interaction

Biochemical and Biophysical Research Communications - BBRC, Vol. 352, (2) : 444-448

Lundberg, Pernilla; Koskinen, Cecilia; Baldock, Paul A; et al.

Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes.

Biochemical and Biophysical Research Communications - BBRC, Vol. 352, (1) : 193-197

Olsson, Mattias; Nilsson, Anna; Oldenborg, Per-Arne

Lack of CD47 on nonhematopoietic cells induces split macrophage tolerance to CD47null cells

Proceedings of the National Academy of Sciences of the United States of America, National academy of sciences 2007, Vol. 104, (34) : 13744-13749

Wang, Hui; Madariaga, Maria Lucia; Wang, Shumei; et al.

Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.

Blood, Vol. 109, (2) : 836-42

Wang, Hui; VerHalen, Jon; Madariaga, Maria Lucia; et al.

Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration.

Journal of Immunology, Vol. 176, (10) : 5772-8

Hagnerud, Sven; Manna, Partha Pratim; Cella, Marina; et al.

Mutational analysis of the mechanism of negative regulation by SRC homology 2 domain-containing protein tyrosine phosphatase substrate-1 of phagocytosis in macrophages.

Journal of Immunology, Vol. 177, (5) : 3123-32

Ikeda, Hiroshi; Okazawa, Hideki; Ohnishi, Hiroshi; et al.

Enhanced phagocytosis of CD47-deficient red blood cells by splenic macrophages requires SHPS-1.

Biochemical and Biophysical Research Communications - BBRC, Vol. 343, (4) : 1197-200

Ishikawa-Sekigami, Tomomi; Kaneko, Yoriaki; Saito, Yasuyuki; et al.

CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42.

Journal of Neuroscience, Vol. 26, (48) : 12397-407

Murata, Takaaki; Ohnishi, Hiroshi; Okazawa, Hideki; et al.

Hematologic Diseases: Autoimmune Hemolytic Anemia and Immune Thrombocytopenic Purpura

Immunogenetics of Autoimmune Disease : -

Olsson, Mattias; Hagnerud, Sven; Hedelius, David U R; et al.

Target cell CD47 regulates macrophage activation and erythrophagocytosis.

Transfusion Clinique et Biologique, Vol. 13, (1-2) : 39-43

Olsson, Mattias; Nilsson, Anna; Oldenborg, Per-Arne

Insulin inhibits phagocytosis in normal human neutrophils via PKCalpha/beta-dependent priming of F-actin assembly.

Inflammation Research, Vol. 55, (3) : 85-91

Saiepour, Daniel; Sehlin, Janove; Oldenborg, Per-Arne

Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte

Cell, Vol. 123, (2) : 321-334

Gardai, Shyra J; McPhillips, Kathleen A; Frasch, S Courtney; et al.

View publications in DiVA

Research groups

Head of research

Per-Arne Oldenborg-research group

Research projects

28 October 2011 until 31 December 2013

CD47 and signal regulatory protein a (SIRP a) modulates innate immune and autoimmune responses