Lucia Mincheva-Nilsson

Pregnancy and cancer share common aims – to escape attack by the immune system.

Research qualifications: Docent

Contact

lucia.mincheva-nilsson@umu.se

+46 90 785 22 37

Works as

Professor emerita at Department of Clinical Microbiology Section: Clinical Immunology

6B, Universitetssjukhuset, Klinisk immunologi, plan 1 Umeå universitet, 901 85 Umeå

In a collaborative translational clinical and basic research project we study:

normal pregnancy and related disorders such as pre-eclampsia, and
high-grade serous carcinoma of the ovary (HGSC) and severe endometriosis that can impair fertility and booster the risk for HGSC.

Endometriotic tissue-derived exosomes downregulate NKg2D-mediated cytotoxicity and promote apoptosis: mechanisms for survival of ectopic endometrial tissue in endometriosis

Journal of Immunology, The American Association of Immunologists 2024, Vol. 213, (5) : 567-576

Björk, Emma; Israelsson, Pernilla; Nagaev, Ivan; et al.

NKG2D-mediated cytotoxicity improves after primary surgery for high-grade serous ovarian cancer

American Journal of Reproductive Immunology, John Wiley & Sons 2023, Vol. 89, (1)

Israelsson, Pernilla; Björk, Emma; Nagaev, Ivan; et al.

Immunosuppressive Protein Signatures Carried by Syncytiotrophoblast-Derived Exosomes and Their Role in Human Pregnancy

Frontiers in Immunology, Frontiers Media S.A. 2021, Vol. 12

Mincheva-Nilsson, Lucia

Rift valley fever virus propagates in human villous trophoblast cell lines and induces cytokine mrna responses known to provoke miscarriage

Viruses, MDPI 2021, Vol. 13, (11)

Yong-Dae, Gwon; Mahani, Seyed Alireza Nematollahi; Nagaev, Ivan; et al.

Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity

American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (4)

Björk, Emma; Vinnars, Marie-Therese; Nagaev, Ivan; et al.

The chimera-type galectin-3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus

American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (6)

Freitag, Nancy; Tirado-Gonzalez, Irene; Barrientos, Gabriela; et al.

Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer: Methodological considerations on the choice of analytical method for cytokine analyses

American Journal of Reproductive Immunology, John Wiley & Sons 2020, Vol. 84, (1)

Israelsson, Pernilla; Dehlin, Eva; Nagaev, Ivan; et al.

Assessment of cytokine mRNA expression profiles in tumor microenvironment and peripheral blood mononuclear cells of patients with high-grade serous carcinoma of the ovary

International Journal of Gynecological Cancer, BMJ Publishing Group Ltd 2019, Vol. 29 : A138-A138

Israelsson, Pernilla; Labani-Motlagh, Alireza; Nagaev, Ivan; et al.

Enhanced Th1 and inflammatory mRNA responses upregulate NK cell cytotoxicity and NKG2D ligand expression in human pre-eclamptic placenta and target it for NK cell attack

American Journal of Reproductive Immunology, John Wiley & Sons 2018, Vol. 80, (1)

Vinnars, Marie-Therese; Björk, Emma; Nagaev, Ivan; et al.

Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8(+) T Cytotoxic Lymphocytes and CD19(+) B Lymphocytes in Rheumatoid Arthritis Responding to TNF- Inhibition

Scandinavian Journal of Immunology, John Wiley & Sons 2017, Vol. 86, (1) : 31-39

Andersen, M.; Nagaev, Ivan; Meyer, M. K.; et al.

Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity

Immunity, Inflammation and Disease, Wiley-Blackwell 2017, Vol. 5, (4) : 541-550

Holm, Anna; Nagaeva, Olga; Nagaev, Ivan; et al.

Assessment of cytokine mRNA expression profiles in tumor microenvironment and peripheral blood mononuclear cells of patients with high-grade serous carcinoma of the ovary

Journal of Cancer Science & Therapy, Vol. 9, (5) : 422-429

Israelsson, Pernilla; Labani-Motlagh, Alireza; Nagaev, Ivan; et al.

Mood and oxytocin blood levels in physically active women with and without oral contraceptive use in relation to seasonal daylight variation

International Journal of Sports and Exercise Medicine, Vol. 3, (3)

Wikström-Frisén, Lisbeth; Larsson, Peter; Mincheva Nilsson, Lucia; et al.

Differential expression of ligands for NKG2D and DNAM-1 receptors by epithelial ovarian cancer-derived exosomes and its influence on NK cell cytotoxicity

Tumor Biology, Vol. 37, (4) : 5455-5466

Labani-Motlagh, Alireza; Israelsson, Pernilla; Ottander, Ulrika; et al.

Isolation and characterization of exosomes from cultures of tissue explants and cell lines

Current Protocols in Immunology, Wiley-Blackwell 2016, Vol. 2016 : 14.42.1-14.42.21

Mincheva-Nilsson, Lucia; Baranov, Vladimir; Nagaeva, Olga; et al.

Impact of Season and Oral Contraceptive use on Cortisol Levelsin Physically Active Women

Journal of Exercise, Sports & Orthopedics, Vol. 3, (2)

Wikström-Frisén, Lisbeth; Nordström, Anna; Mincheva-Nilsson, Lucia; et al.

Dynamics of cytokine mRNA expression and fecal biomarkers in school-children undergoing a double-blind placebo-controlled food challenge series

Cytokine, Vol. 88 : 259-266

Winberg, Anna; Nagaeva, Olga; Nagaev, Ivan; et al.

Adalimumab (Humira (R)) normalizes melanocortin receptor subtype 2, 3, and 4 expression in CD8+, CD14+, and CD19+leucocyte subsets in rheumatoid arthritis

Scandinavian Journal of Rheumatology, Informa Healthcare 2014, Vol. 43, (Suppl. 127) : 25-26 Meeting Abstr. PP119

Andersen, M.; Olesen, M. K.; Nagaev, Ivan; et al.

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion

PLOS ONE, Vol. 9, (9) : e108925-

Lundholm, Marie; Schröder, Mona; Nagaeva, Olga; et al.

Cancer exosomes and NKG2D receptor-ligand interactions: impairing NKG2D-mediated cytotoxicity and anti-tumour immune surveillance

Seminars in Cancer Biology, Vol. 28 : 24-30

Mincheva-Nilsson, Lucia; Baranov, Vladimir

Placenta-derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: immune modulation for pregnancy success

American Journal of Reproductive Immunology, Wiley-Blackwell 2014, Vol. 72, (5) : 440-457

Mincheva-Nilsson, Lucia; Baranov, Vladimir

Serological assessment for celiac disease in IgA deficient adults

PLOS ONE, PLoS one 2014, Vol. 9, (4) : e93180-

Wang, Ning; Truedsson, Lennart; Elvin, Kerstin; et al.

Exosomen: intercellulär signalbärare med framtidspotential. Kan ge nya diagnostiska och terapeutiska möjligheter.

Läkartidningen, Läkartidningen förlag AB 2013, Vol. 110, (46) : 2050-2052

Ronquist, Gunnar; Lötvall, Jan; Gabrielsson, Susanne; et al.

Characterization of human thymic exosomes

PLOS ONE, Vol. 8, (7) : e67554-

Skogberg, Gabriel; Gudmundsdottir, Judith; van der Post, Sjoerd; et al.

Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome-mediated immune privilege of the fetus

Journal of Immunology, The American Association of Immunologists 2013, Vol. 191, (11) : 5515-5523

Stenqvist, Ann-Christin; Nagaeva, Olga; Baranov, Vladimir; et al.

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

Molecular human reproduction, Vol. 19, (1) : 43-53

Tirado-Gonzalez, Irene; Freitag, Nancy; Barrientos, Gabriela; et al.

Dermal Melanocortin Receptor Rebound in Diffuse Systemic Sclerosis after Anti-TGF ss 1 Antibody Therapy

Scandinavian Journal of Immunology, Hoboken: Wiley-Blackwell 2012, Vol. 76, (5) : 478-482

Andersen, G. Neumann; Andersen, M.; Nagaeva, Olga; et al.

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

PLoS biology, Public library of science 2012, Vol. 10, (12) : e1001450-

Kalra, Hina; Simpson, Richard J; Ji, Hong; et al.

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

Molecular Therapy, New York: Nature Publishing Group 2012, Vol. 20, (5) : 960-971

Maguire, Casey A.; Balaj, Leonora; Sivaraman, Sarada; et al.

The Melanocortin System: A New and Important Actor on the Scene of Systemic Sclerosis

Arthritis and Rheumatism, Malden: Wiley-Blackwell 2011, Vol. 63, (10) : S908-S908

Andersen, Grethe N.; Nagaeva, Olga; Mincheva-Nilsson, Lucia; et al.

Cytokine mRNA profile of alveolar T lymphocytes and macrophages in patients with systemic sclerosis suggests a local Tr1 response

Scandinavian Journal of Immunology, Oslo: Univ.forl. 2011, Vol. 74, (3) : 272-81

Andersen, Grethe N.; Nilsson, Kenneth; Nagaeva, O; et al.

Maternal Foxp3 expressing CD4+ CD25+ and CD4+ CD25- regulatory T-cell populations are enriched in human early normal pregnancy decidua: a phenotypic study of paired decidual and peripheral blood samples.

American Journal of Reproductive Immunology and Microbiology, John Wiley & Sons 2011, Vol. 66, (Suppl 1) : 44-56

Dimova, Tanya; Nagaeva, Olga; Stenqvist, Ann-Christin; et al.

Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells

PLOS ONE, Vol. 6, (2) : e16899-

Hedlund, Malin; Nagaeva, Olga; Kargl, Dominic; et al.

Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells

PLOS ONE, Public Library of Science 2011, Vol. 6, (2)

Hedlund, Malin; Nagaeva, Olga; Kargl, Dominic; et al.

Studie av larynxpapillom i norra Sverige: två fall av onkogena HPV bland 26 patienter: [A study of laryngeal papilloma in northern Sweden: Two cases of oncogenic HPV among 26 patients]

Läkartidningen, Svergies läkarförbund 2011, Vol. 108, (21) : 1187-1189

Olofsson, Katarina; Loizou, Christos; Evander, Magnus; et al.

Placental exosome-mediated immune protection of the fetus: feeling groovy in a cloud of exosomes

Expert Review of Obstetrics & Gynecology, Expert Reviews LTD 2010, Vol. 5, (5) : 619-634

Mincheva-Nilsson, Lucia

The role of placental exosomes in reproduction

American Journal of Reproductive Immunology and Microbiology, Vol. 63, (6) : 520-533

Mincheva-Nilsson, Lucia; Baranov, Vladimir

Low agreement between radio binding assays in analyzing glutamic acid decarboxylase (GAD65Ab) autoantibodies in patients classified with type 2 diabetes.

Autoimmunity, Informa Healthcare 2009, Vol. 42, (6) : 507-514

Daka, Bledar; Svensson, Maria K; Lernmark, Åke; et al.

Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function

Journal of Immunology, Vol. 183, (1) : 340-351

Hedlund, Malin; Stenqvist, Ann-Christin; Nagaeva, Olga; et al.

Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer.

British journal of cancer, Vol. 100, (10) : 1603-1607

Nilsson, Jonas; Skog, Johan; Nordstrand, Annika; et al.

Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis

Respiratory Medicine, Vol. 103, (2) : 301-308

Sehlstedt, Maria; Andersen, Grethe Neumann; Nilsson, Kenneth; et al.

An efficient optimized method for isolation of villous trophoblast cells from human early pregnancy placenta suitable for functional and molecular studies

American Journal of Reproductive Immunology and Microbiology, Vol. 60, (1) : 33-42

Stenqvist, Ann-Christin; Chen, Ting; Hedlund, Malin; et al.

Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis.

Respiratory Medicine, Vol. 101, (10) : 2199-2206

Andersen, Grethe Neumann; Nilsson, Kenneth; Pourazar, Jamshid; et al.

Immune cells and molecules in pregnancy: friends or foes to the fetus?

Expert Review of Clinical Immunology, Future Drugs LTD 2006, Vol. 2, (3) : 457-470

Mincheva-Nilsson, Lucia

Placenta-derived soluble MHC class I chain-related molecules down-regulate NKG2D receptor on peripheral blood mononuclear cells during human pregnancy: a possible novel immune escape mechanism for fetal survival

Journal of Immunology, Vol. 176, (6) : 3585-3592

Mincheva-Nilsson, Lucia; Nagaeva, Olga; Chen, Ting; et al.

Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3 and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leucocytes

Scandinavian Journal of Immunology, Oxford: Blackwell Publishing 2005, Vol. 61, (3) : 279-284

Andersen, Grethe; Hägglund, M; Nagaeva, Olga; et al.

Assessment of vascular function in systemic sclerosis: indications of the development of nitrate tolerance as a result of enhanced endothelial nitric oxide production

Arthritis and Rheumatism, Vol. 46, (5) : 1324-1332

Andersen, Grethe Neumann; Mincheva-Nilsson, Lucia; Kazzam, Elsadig; et al.

Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular adhesion molecule 1

Arthritis and Rheumatism, Vol. 43, (5) : 1085-1093

Andersen, Grethe Neumann; Caidahl, Kenneth; Kazzam, Elsadig; et al.

Lipids are a constitutive component of cytolytic granules.

Histochemistry and Cell Biology, Vol. 114, (2) : 167-71

Baranov, Vladimir; Nagaeva, Olga; Hammarström, Sten; et al.

Activated human gamma delta T lymphocytes express functional lactoferrin receptors.

Scandinavian Journal of Immunology, Vol. 46, (6) : 609-18

Mincheva-Nilsson, Lucia; Hammarström, Sten; Hammarström, Marie-Louise

View publications in DiVA

Research groups

Head of research

Lucia Mincheva-Nilsson