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Staff photo Helena Edlund

Helena Edlund

PhD

Professor of Molecular Developmental Biology

Head of the Section of Molecular Medicin, Dept. of Medical and Translational Biology

Research qualifications: Docent
0000-0002-3553-7348

Contact

E-mail
helena.edlund@umu.se
Phone
+46 90 786 67 99

Works as

Affiliation
Professor at Department of Medical and Translational Biology Section: Section for Molecular Medicine
Location
hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå
Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice
PLOS Genetics, Public Library of Science (PLoS) 2025, Vol. 21, (1)
Zhang, Ying; He, Lihong; Gundelach, Justin; et al.
Myofiber-specific lipidomics unveil differential contributions to insulin sensitivity in individuals of African and European ancestry
Heliyon, Elsevier 2024, Vol. 10, (12)
Eurén, Tova; Gower, Barbara; Steneberg, Pär; et al.
Acute hyperglycemia induced by hyperglycemic clamp affects plasma Amyloid-β in type 2 diabetes
Journal of Alzheimer's Disease, IOS Press 2024, Vol. 99, (3) : 1033-1046
Rolandsson, Olov; Tornevi, Andreas; Steneberg, Pär; et al.
O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
Communications Biology, Springer Nature 2023, Vol. 6, (1)
Norlin, Stefan; Axelsson, Jan; Ericsson, Madelene; et al.
AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
Communications Biology, Nature Publishing Group 2021, Vol. 4, (1)
Ericsson, Madelene; Steneberg, Pär; Nyrén, Rakel; et al.
Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
López-Pérez, Ana R.; Norlin, Stefan; Steneberg, Pär; et al.
alpha-Synuclein promotes IAPP fibril formation in vitro and beta-cell amyloid formation in vivo in mice
Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)
Mucibabic, Marija; Steneberg, Pär; Lidh, Emmelie; et al.
The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques
Journal of Allergy and Clinical Immunology, MOSBY-ELSEVIER 2018, Vol. 142, (2) : 470-482.e12
Nagatake, Takahiro; Shiogama, Yumiko; Inoue, Asuka; et al.
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival
Development, COMPANY OF BIOLOGISTS LTD 2018, Vol. 145, (1)
Norlin, Stefan; Parekh, Vishal; Edlund, Helena
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
JCI INSIGHT, American Society for Clinical Investigation 2018, Vol. 3, (12)
Steneberg, Pär; Lindahl, Emma; Dahl, Ulf; et al.
The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice
Diabetologia, Vol. 59, (5) : 1007-1011
Ali, Yusuf; Diez, Juan; Selander, Lars; et al.
Asna1/TRC40 Controls beta-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport
Diabetes, Vol. 65, (1) : 110-119
Norlin, Stefan; Parekh, Vishal S.; Naredi, Peter; et al.
Insulin-degrading enzyme prevents alpha-synuclein fibril formation in a nonproteolytical manner
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Sharma, Sandeep K; Chorell, Erik; Steneberg, Pär; et al.
Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
Journal of Biological Chemistry, Vol. 290, (31) : 19034-19043
Steneberg, Pär; Sykaras, Alexandros G.; Backlund, Fredrik; et al.
Pdx1 Maintains beta Cell Identity and Function by Repressing an alpha Cell Program
Cell Metabolism, Vol. 19, (2) : 259-271
Gao, Tao; McKenna, Brian; Li, Changhong; et al.
The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of alpha-Synuclein Levels in beta-Cells
Diabetes, Vol. 62, (6) : 2004-2014
Steneberg, Pär; Bernardo, Lisandro; Edfalk, Sara; et al.
The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human β-cells and its targeted inactivation impairs insulin secretion
Endocrinology, Baltimore: Williams & Wilkins 2011, Vol. 152, (10) : 3717-3727
Medina, Mayrin C.; Molina, Judith; Gadea, Yelena; et al.
The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity
Endocrinology, Vol. 150, (1) : 87-97
Boucher, Marie-Josée; Simoneau, Mélanie; Edlund, Helena
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas.
Gene Expression Patterns, Vol. 9, (4) : 193-9
Correa-Medina, Mayrin; Bravo-Egana, Valia; Rosero, Samuel; et al.
Endocrine cell clustering during human pancreas development
Journal of Histochemistry and Cytochemistry, Vol. 57, (9) : 811-824
Jeon, Jongmin; Correa-Medina, Mayrin; Ricordi, Camillo; et al.
MFng is dispensable for mouse pancreas development and function
Molecular and Cellular Biology, Vol. 29, (8) : 2129-2138
Svensson, Per; Bergqvist, Ingela; Norlin, Stefan; et al.
Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
Diabetes, Vol. 57, (9) : 2280-7
Edfalk, Sara; Steneberg, Pär; Edlund, Helena
Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells
PLoS ONE, Vol. 3, (7) : e2841-
Oström, Maria; Loffler, Kelly A; Edfalk, Sara; et al.
Toward a renewable source of pancreatic beta-cells.
Nature biotechnology, Vol. 26, (4) : 397-8
Ricordi, Camillo; Edlund, Helena
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Cell Metabolism, Vol. 5, (3) : 207-219
Goulley, Joan; Dahl, Ulf; Baeza, Nathalie; et al.
Gene array identification of Ipf1/Pdx1 -/- regulated genes in pancreatic progenitor cells.
BMC Developmental Biology, Vol. 7, (1) : 129-
Svensson, Per; Williams, Cecilia; Lundeberg, Joakim; et al.
Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms.
The Journal of Biological Chemistry, Vol. 281, (10) : 6395-403
Boucher, Marie-Josée; Selander, Lars; Carlsson, Lennart; et al.
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.
Development, Vol. 133, (22) : 4439-50
Fujitani, Yoshio; Fujitani, Shuko; Luo, Huijun; et al.
TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro.
Diabetes, Vol. 54, (3) : 720-6
Domínguez-Bendala, Juan; Klein, Dagmar; Ribeiro, Melina; et al.
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Diabetes, Vol. 54, (2) : 482-91
Li, Yazhou; Cao, Xiemin; Li, Li-Xin; et al.
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish.
Developmental Biology, Vol. 285, (1) : 211-23
Mavropoulos, Anastasia; Devos, Nathalie; Biemar, Frédéric; et al.
Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion.
Diabetes, Vol. 54, (1) : 125-32
Norlin, Stefan; Ahlgren, Ulf; Edlund, Helena
Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.
Diabetes, Vol. 54, (10) : 2844-2851
Papadopoulou, Stella; Edlund, Helena
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Cell Metabolism, Vol. 1, (4) : 245-58
Steneberg, Pär; Rubins, Nir; Bartoov-Shifman, Reut; et al.
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Molecular and Cellular Biology, Vol. 23, (17) : 6075-6085
Crabtree, Judy S; Scacheri, Peter C; Ward, Jerrold M; et al.
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
Developmental Dynamics, Vol. 228, (2) : 185-193
Hart, Alan; Papadopoulou, Stella; Edlund, Helena
View publications in DiVA

Research groups

Head of research
Helena Edlund