Gunilla Olivecrona

Research qualifications: Docent

Contact

Works as

Professor emerita at Department of Medical Biosciences

By 6M, vån 3, Sjukhusområdet Umeå universitet, 901 87 Umeå

Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice

Cardiovascular Research, Oxford University Press 2024, Vol. 120, (17) : 2179-2190

Modder, Melanie; Panhuis, Wietse In Het; Li, Mohan; et al.

Visualizing increased uptake of [18F]FDG and [18F]FTHA in kidneys from obese high-fat diet fed C57BL/6J mice using PET/CT ex vivo

PLOS ONE, Public Library of Science (PLoS) 2023, Vol. 18

Nyrén, Rakel; Scherman, Henrik; Axelsson, Jan; et al.

Role of lipoprotein lipase activity measurement in the diagnosis of familial chylomicronemia syndrome: diagnosis of the Familial Chylomicronemia Syndrome

Journal of Clinical Lipidology, Elsevier 2023, Vol. 17, (2) : 272-280

Rioja, José; Ariza, María José; Benítez-Toledo, María José; et al.

ANGPTL4 silencing via antisense oligonucleotides reduces plasma triglycerides and glucose in mice without causing lymphadenopathy

Journal of Lipid Research, American Society for Biochemistry and Molecular Biology 2022, Vol. 63, (7)

Deng, Mingjuan; Kutrolli, Elda; Sadewasser, Anne; et al.

Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma

Journal of Lipid Research, American Society for Biochemistry and Molecular Biology 2022, Vol. 63, (1)

Kovrov, Oleg; Landfors, Fredrik; Saar-Kovrov, Valeria; et al.

Maternal Adipose Tissue Expansion, A Missing Link in the Prediction of Birth Weight Centile

Journal of Clinical Endocrinology and Metabolism, Oxford University Press 2020, Vol. 105, (3) : E814-E825

Jarvie, Eleanor M.; Stewart, Frances M.; Ramsay, Jane E.; et al.

Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (8) : 4337-4346

Kristensen, Kristian K.; Leth-Espensen, Katrine Zinck; Mertens, Haydyn D. T.; et al.

Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

Molecular Metabolism, Elsevier 2020, Vol. 40

Ruppert, Philip M. M.; Michielsen, Charlotte C. J. R.; Hazebroek, Eric J.; et al.

On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity

Journal of Lipid Research, American Society for Biochemistry and Molecular Biology 2019, Vol. 60, (4) : 783-793

Kovrov, Oleg; Kristensen, Kristian Kølby; Larsson, Erika; et al.

Lipoprotein lipase in mouse kidney: effects of nutritional status and high-fat diet

American Journal of Physiology - Renal Physiology, American Physiological Society 2019, Vol. 316, (3) : F558-F571

Nyrén, Rakel; Makoveichuk, Elena; Malla, Sandhya; et al.

Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice[S]

Journal of Lipid Research, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2019, Vol. 60, (10) : 1741-1754

Oteng, Antwi-Boasiako; Ruppert, Philip M. M.; Boutens, Lily; et al.

Decreased lipogenesis-promoting factors in adipose tissue in postmenopausal women with overweight on a Paleolithic-type diet

European Journal of Nutrition, Springer 2018, Vol. 57, (8) : 2877-2886

Blomquist, Caroline; Chorell, Elin; Ryberg, Mats; et al.

Lipoprotein Lipase Deficiency Impairs Bone Marrow Myelopoiesis and Reduces Circulating Monocyte Levels

Arteriosclerosis, Thrombosis and Vascular Biology, Vol. 38, (3) : 509-519

Chang, Chuchun L.; Garcia-Arcos, Itsaso; Nyrén, Rakel; et al.

A disordered acidic domain in GPIHBP1 harboring a sulfated tyrosine regulates lipoprotein lipase

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2018, Vol. 115, (26) : E6020-E6029

Kristensen, Kristian K.; Midtgaard, Søren Roi; Mysling, Simon; et al.

On the regulatory importance of 27-hydroxycholesterol in mouse liver

Journal of Steroid Biochemistry and Molecular Biology, Elsevier 2017, Vol. 169 : 10-21

Heverin, Maura; Ali, Zeina; Olin, Maria; et al.

High concentrations of Angiopoietin-like Protein 4 detected in serum from patients with rheumatoid arthritis can be explained by non-specific antibody reactivity

PLOS ONE, Vol. 12, (1)

Makoveichuk, Elena; Ruge, Toralph; Nilsson, Solveig; et al.

TNF-alpha decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Elsevier 2017, Vol. 1862, (5) : 533-540

Makoveichuk, Elena; Vorrsjö, Evelina; Olivecrona, Thomas; et al.

Aromatic residues in the C terminus of apolipoprotein C-III mediate lipid binding and LPL inhibition

JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017, Vol. 58, (5) : 840-852

Meyers, Nathan L.; Larsson, Mikael; Vorrsjo, Evelina; et al.

Lipoprotein lipase activity and interactions studied in human plasma by isothermal titration calorimetry

Journal of Lipid Research, Vol. 58, (1) : 279-288

Reimund, Mart; Kovrov, Oleg; Olivecrona, Gunilla; et al.

Peroxisome proliferator-activated receptor activation favours selective subcutaneous lipid deposition by coordinately regulating lipoprotein lipase modulators, fatty acid transporters and lipogenic enzymes

Acta Physiologica, Vol. 217, (3) : 227-239

Blanchard, P. G.; Turcotte, V.; Cote, M.; et al.

Novel mutations in the GPIHBP1 gene identified in 2 patients with recurrent acute pancreatitis

Journal of Clinical Lipidology, Vol. 10, (1) : 92-100

Jose Ariza, Maria; Luis Martinez-Hernandez, Pedro; Ibarretxe, Daiana; et al.

Polarized trafficking of the sorting receptor SorLA in neurons and MDCK cells

The FEBS Journal, Wiley-Blackwell 2016, Vol. 283, (13) : 2476-2493

Klinger, Stine C.; Højland, Anne; Jain, Shweta; et al.

Free fatty acid transfer across the placenta facilitated by lipoprotein lipase and its relationship with fetal adiposity

British Journal of Obstetrics and Gynecology, Vol. 123 : 86-86

McMurray, C.; Jordan, F.; Olivecrona, Gunilla; et al.

The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

eLIFE, Vol. 5

Mysling, Simon; Kolby Kristensen, Kristian; Larsson, Mikael; et al.

Diabetes and Hypertension Consistently Predict the Presence and Extent of Coronary Artery Calcification in Symptomatic Patients: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Basel, Switzerland: MDPI 2016, Vol. 17, (9)

Nicoll, Rachel; Zhao, Ying; Ibrahimi, Pranvera; et al.

Role of lipoprotein lipase in lipid metabolism

Current Opinion in Lipidology, Vol. 27, (3) : 233-241

Olivecrona, Gunilla

SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity

Journal of Clinical Investigation, American Society for Clinical Investigation 2016, Vol. 126, (7) : 2706-2720

Schmidt, Vanessa; Schulz, Nadja; Yan, Xin; et al.

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Nature Communications, Vol. 7

Valleix, Sophie; Verona, Guglielmo; Jourde-Chiche, Noémie; et al.

TREM2 regulates microglial cell activation in response to demyelination in vivo

Acta Neuropathologica, Vol. 129, (3) : 429-447

Cantoni, Claudia; Bollman, Bryan; Licastro, Danilo; et al.

Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo

European Journal of Medicinal Chemistry, Elsevier 2015, Vol. 103 : 191-209

Caraballo, Remi; Larsson, Mikael; Nilsson, Stefan K.; et al.

A Pressure-dependent Model for the Regulation of Lipoprotein Lipase by Apolipoprotein C-II

Journal of Biological Chemistry, Bethesda: American Society for Biochemistry and Molecular Biology 2015, Vol. 290, (29) : 18029-18044

Meyers, Nathan L; Larsson, Mikael; Olivecrona, Gunilla; et al.

A pressure-dependent model for the regulation of lipoprotein lipase by apolipoprotein C-II

The FASEB Journal, Vol. 29, (Supplement 1)

Meyers, Nathan; Larsson, Mikael; Olivecrona, Gunilla; et al.

Evidence for Two Distinct Binding Sites for Lipoprotein Lipase on Glycosylphosphatidylinositol-anchored High Density Lipoprotein-binding Protein 1 (GPIHBP1)

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2015, Vol. 290, (22) : 13919-13934

Reimund, Mart; Larsson, Mikael; Kovrov, Oleg; et al.

The tissue distribution of lipoprotein lipase determines where chylomicrons bind

Journal of Lipid Research, Vol. 56, (3) : 588-598

Savonen, Roger; Hiden, Michaela; Hultin, Magnus; et al.

Acute alcohol consumption downregulates lipoprotein lipase activity in vivo

Metabolism: Clinical and Experimental, Elsevier 2015, Vol. 64, (11) : 1592-1596

Zemankova, Katerina; Makoveichuk, Elena; Vlasakova, Zuzana; et al.

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, (11) : E1043-E1052

Catoire, MilSNe; Alex, Sheril; Paraskevopulos, Nicolas; et al.

Identification of a small molecule that stabilizes lipoprotein lipase in vitro and lowers triglycerides in vivo

Biochemical and Biophysical Research Communications - BBRC, Elsevier 2014, Vol. 450, (2) : 1063-1069

Larsson, Mikael; Caraballo, Rémi; Ericsson, Madelene; et al.

Response of angiopoietin-like proteins 3 and 4 to haemodialysis

International Journal of Artificial Organs, Vol. 37, (1) : 13-20

Mahmood, Dana; Makoveichuk, Elena; Nilsson, Solveig; et al.

Lipoprotein lipase activity is favoured by peritoneal dialysis compared to hemodialysis

Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 74, (4) : 296-300

Mahmood, Dana; Nilsson, Solveig; Olivecrona, Gunilla; et al.

Hvorfor hypertriglyseridemi fø rer til pankreatitt

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Den norske legeforening 2013, Vol. 133, (1) : 14-15

Christophersen, Bjørn; Sørby, Randi; Osmundsen, Harald; et al.

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4

American Journal of Respiratory and Critical Care Medicine, Vol. 188, (2) : 240-248

Drager, Luciano F.; Yao, Qiaoling; Hernandez, Karen L.; et al.

Depletion of FOXP3(+) regulatory T cells promotes hypercholesterolemia and atherosclerosis

Journal of Clinical Investigation, Vol. 123, (3) : 1323-1334

Klingenberg, Roland; Gerdes, Norbert; Badeau, Robert M; et al.

Apolipoproteins C-I and C-III Inhibit Lipoprotein Lipase Activity by Displacement of the Enzyme from Lipid Droplets

Journal of Biological Chemistry, Vol. 288, (47) : 33997-34008

Larsson, Mikael; Vorrsjö, Evelina; Talmud, Philippa; et al.

Inactivation of lipoprotein lipase in 3T3-L1 adipocytes by angiopoietin-like protein 4 requires that both proteins have reached the cell surface

Biochemical and Biophysical Research Communications - BBRC, Elsevier 2013, Vol. 441, (4) : 941-946

Makoveichuk, Elena; Vorrsjö, Evelina; Olivecrona, Thomas; et al.

Fasting apolipoprotein B48 is a marker for peripheral arterial disease in type 2 diabetes

Acta Diabetologica, Vol. 50, (3) : 383-389

Mancera-Romero, J.; Sanchez-Chaparro, M. A.; Rioja, J.; et al.

Maternal Obesity Is Associated With the Formation of Small Dense LDL and Hypoadiponectinemia in the Third Trimester

Journal of Clinical Endocrinology and Metabolism, Vol. 98, (2) : 643-652

Meyer, Barbara J.; Stewart, Frances M.; Brown, Elizabeth A.; et al.

Intermittent hypoxia inhibits clearance of triglyceride-rich lipoproteins and inactivates adipose lipoprotein lipase in a mouse model of sleep apnoea

European Heart Journal, Oxford: Oxford University Press 2012, Vol. 33, (6) : 783-U33

Drager, Luciano F.; Li, Jianguo; Shin, Mi-Kyung; et al.

Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue.

BMC Physiology, BioMed Central (BMC) 2012, Vol. 12 : 13-

Kroupa, Olessia; Vorrsjö, Evelina; Stienstra, Rinke; et al.

Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury

American Journal of Physiology - Renal Physiology, Vol. 303, (3) : F437-F448

Li, Shenyang; Nagothu, Kiran; Ranganathan, Gouri; et al.

Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed

Biochemical and Biophysical Research Communications - BBRC, San Diego: Elsevier 2012, Vol. 425, (2) : 138-143

Makoveichuk, Elena; Sukonina, Valentina; Kroupa, Olessia; et al.

View publications in DiVA

Research groups

Head of research

Gunilla Olivecrona

Research projects

28 February 2007 until 31 December 2009

Role of lipoprotein lipase for plasma lipid transport