Dan Hultmark

Research qualifications: Docent

Contact

dan.hultmark@umu.se

+46 90 785 67 87

Works as

Professor emeritus at Department of Molecular Biology Section: Research group Dan Hultmark

6K och 6L, Sjukhusområdet, 6L-243 Umeå universitet, 901 87 Umeå

Pore-forming toxin-like proteins in the anti-parasitoid immune response of drosophila

Journal of Innate Immunity, S. Karger 2025, Vol. 17, (1) : 10-28

Magyar, Lilla B.; Ábrahám, Edit; Lipinszki, Zoltán; et al.

Cellular immunity of Drosophila willistoni reveals novel complexity in insect anti-parasitoid defense

Cells, MDPI 2024, Vol. 13, (7)

Cinege, Gyöngyi; Fodor, Kinga; Magyar, Lilla B.; et al.

Obituary of Prof. Uli Theopold, 1957–2023

Journal of Innate Immunity, S. Karger 2024, Vol. 16, (1) : 31-32

Engström, Ylva; Lemaitre, Bruno; Hultmark, Dan

Editorial: community series in recent advances in Drosophila cellular and humoral innate immunity: volume II

Frontiers in Immunology, Frontiers Media S.A. 2024, Vol. 15

Vesala, Laura; Hultmark, Dan; Valanne, Susanna

Distinctive features of Zaprionus indianus hemocyte differentiation and function revealed by transcriptomic analysis

Frontiers in Immunology, Frontiers Media S.A. 2023, Vol. 14

Cinege, Gyöngyi; Magyar, Lilla B.; Kovács, Henrietta; et al.

Broad Ultrastructural and Transcriptomic Changes Underlie the Multinucleated Giant Hemocyte Mediated Innate Immune Response against Parasitoids

Journal of Innate Immunity, S. Karger 2022, Vol. 14, (4) : 335-354

Cinege, Gyöngyi; Magyar, Lilla B.; Kovács, Attila L.; et al.

Hematopoietic plasticity mapped in Drosophila and other insects

eLIFE, eLife Sciences Publications 2022, Vol. 11

Hultmark, Dan; Andó, István

Structure of Nora virus at 2.7 angstrom resolution and implications for receptor binding, capsid stability and taxonomy

Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)

Laurinmäki, Pasi; Shakeel, Shabih; Ekström, Jens-Ola; et al.

Recent Advances in Drosophila Cellular and Humoral Innate Immunity

Frontiers in Immunology, Frontiers Media S.A. 2020, Vol. 11

Vesala, Laura; Hultmark, Dan; Valanne, Susanna

Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens

BMC Genomics, BIOMED CENTRAL LTD 2017, Vol. 18

Doublet, Vincent; Poeschl, Yvonne; Gogol-Doering, Andreas; et al.

Drosophila muscles regulate the immune response against wasp infection via carbohydrate metabolism

Scientific Reports, Nature Publishing Group 2017, Vol. 7

Yang, Hairu; Hultmark, Dan

Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection

PLoS Pathogens, Public library science 2016, Vol. 12, (7)

Anderl, Ines; Vesala, Laura; Ihalainen, Teemu O.; et al.

A Novel Strategy for Live Detection of Viral Infection in Drosophila melanogaster

Scientific Reports, Vol. 6

Ekström, Jens-Ola; Hultmark, Dan

VP3 is crucial for the stability of Nora virus virions

Virus Research, Elsevier 2016, Vol. 223 : 20-27

Sadanandan, Sajna Anand; Ekström, Jens-Ola; Jonna, Venkateswara Rao; et al.

Genetic Screen in Drosophila Larvae Links ird1 Function to Toll Signaling in the Fat Body and Hemocyte Motility

PLOS ONE, Vol. 11, (7)

Schmid, Martin R.; Anderl, Ines; Vo, Hoa T. M.; et al.

Tissue communication in a systemic immune response of Drosophila.

Fly, Philadelphia: Taylor & Francis 2016, Vol. 10, (3) : 115-122

Yang, Hairu; Hultmark, Dan

New ways to make a blood cell

eLIFE, Vol. 4

Anderl, Ines; Hultmark, Dan

Edin expression in the fat body is required in the defense against parasitic wasps in Drosophila melanogaster

PLoS Pathogens, Public library science 2015, Vol. 11, (5)

Vanha-aho, Leena-Maija; Anderl, Ines; Vesala, Laura; et al.

JAK/STAT signaling in Drosophila muscles controls the cellular immune response against parasitoid infection

EMBO Reports, Vol. 16, (12) : 1664-1672

Yang, Hairu; Kronhamn, Jesper; Ekstrom, Jens-Ola; et al.

Control of Drosophila blood cell activation via toll signaling in the fat body

PLOS ONE, Public library of science 2014, Vol. 9, (8)

Schmid, Martin Rudolf; Anderl, Ines; Vesala, L; et al.

The RhoGEF Zizimin-related acts in the Drosophila cellular immune response via the Rho GTPases Rac2 and Cdc42

Developmental and Comparative Immunology, Elsevier 2012, Vol. 38, (1) : 160-168

Sampson, Christopher J; Valanne, Susanna; Fauvarque, Marie-Odile; et al.

Convergent evolution of argonaute-2 slicer antagonism in two distinct insect RNA viruses

PLoS Pathogens, Vol. 8, (8)

van Mierlo, Joël T; Bronkhorst, Alfred W; Overheul, Gijs J; et al.

Functional Characterization of the Infection-Inducible Peptide Edin in Drosophila melanogaster

PLOS ONE, Vol. 7, (5) : e37153-

Vanha-Aho, Leena-Maija; Kleino, Anni; Kaustio, Meri; et al.

Drosophila Nora virus capsid proteins differ from those of other picorna-like viruses

Virus Research, Amsterdam: Elsevier 2011, Vol. 160, (1-2) : 51-58

Ekström, Jens-Ola; Habayeb, Mazen S; Srivastava, Vaibhav; et al.

Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance

Journal of Leukocyte Biology, Society for Leukocyte Biology 2011, Vol. 89, (5) : 649-659

Ulvila, Johanna; Vanha-aho, Leena-Maija; Kleino, Anni; et al.

Uptake of aggregating transthyretin by fat body in a drosophila model for TTR-associated amyloidosis

PloS one, Vol. 5, (12) : e14343-

Pokrzywa, Malgorzata; Dacklin, Ingrid; Vestling, Monika; et al.

RNA silencing in the antiviral innate immune defence--role of DEAD-box RNA helicases

Scandinavian Journal of Immunology, Vol. 71, (3) : 146-158

Ulvila, J; Hultmark, Dan; Rämet, M

Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-κB signaling

Journal of Immunology, American association of immunologists 2010, Vol. 184, (11) : 6188-6198

Valanne, Susanna; Myllymäki, Henna; Kallio, Jenni; et al.

Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.

Science, Vol. 327, (5963) : 343-8

Werren, John H; Richards, Stephen; Desjardins, Christopher A; et al.

The Drosophila Nora virus is an enteric virus, transmitted via feces

Journal of Invertebrate Pathology, Vol. 101 : 29-33

Habayeb, Mazen; Cantera, Rafael; Casanova, Gabriela; et al.

Nora virus persistent infections are not affected by the RNAi machinery.

PLOS ONE, Vol. 4, (5) : e5731-

Habayeb, Mazen S; Ekström, Jens-Ola; Hultmark, Dan

Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, (12) : 4805-4809

Márkus, Róbert; Laurinyecz, Barbara; Kurucz, Eva; et al.

Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292: 246-248. 1981.

Journal of immunology (Baltimore, Md. : 1950), Vol. 182, (11) : 6635-7

Steiner, Håkan; Hultmark, Dan; Engström, Åke; et al.

The N-terminal half of the Drosophila Rel/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes

Developmental and Comparative Immunology, New York: Pergamon Press 2009, Vol. 33, (5) : 690-696

Wiklund, Magda-Lena; Steinert, Stefanie; Junell, Anna; et al.

Pirk is a negative regulator of the Drosophila Imd pathway.

J Immunol, Vol. 180, (8) : 5413-22

Kleino, Anni; Myllymäki, Henna; Kallio, Jenni; et al.

The genome of the model beetle and pest Tribolium castaneum.

Nature, Vol. 452, (7190) : 949-55

Richards, Stephen; Gibbs, Richard A; Weinstock, George M; et al.

Evolution of genes and repeats in the Nimrod superfamily.

Mol Biol Evol, Vol. 25, (11) : 2337-47

Somogyi, Kálmán; Sipos, Botond; Pénzes, Zsolt; et al.

Evolution of genes and genomes on the Drosophila phylogeny.

Nature, Vol. 450, (7167) : 203-18

Drosophila 12 Genomes Consortium, ; Hultmark, Dan

Drosophila immunity: is antigen processing the first step?

Curr Biol, Vol. 17, (1) : R22-4

Hultmark, Dan; Borge Renberg, Karin

The Drosophila NFAT homolog is involved in salt stress tolerance.

Insect Biochem Mol Biol, Vol. 37, (4) : 356-62

Keyser, Pia; Borge Renberg, Karin; Hultmark, Dan

Nimrod, a putative phagocytosis receptor with EGF repeats in Drosophila plasmatocytes.

Curr Biol, Vol. 17, (7) : 649-54

Kurucz, Eva; Márkus, Róbert; Zsámboki, János; et al.

Definition of Drosophila hemocyte subsets by cell-type specific antigens.

Acta Biol Hung, Vol. 58 Suppl : 95-111

Kurucz, Eva; Váczi, B; Márkus, R; et al.

Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis.

European Journal of Neuroscience, Vol. 26, (4) : 913-924

Pokrzywa, Malgorzata; Dacklin, Ingrid; Hultmark, Dan; et al.

Dynamic evolution of the innate immune system in Drosophila.

Nat Genet, Vol. 39, (12) : 1461-8

Sackton, Timothy B; Lazzaro, Brian P; Schlenke, Todd A; et al.

Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells.

J Cell Sci, Vol. 120, (Pt 3) : 502-11

Williams, Michael; Habayeb, Mazen; Hultmark, Dan

Comparative genomic analysis of the Tribolium immune system.

Genome Biol, Vol. 8, (8) : R177.1-16

Zou, Zhen; Evans, Jay; Lu, Zhiqiang; et al.

Immune pathways and defence mechanisms in honey bees Apis mellifera.

Insect Mol Biol, Vol. 15, (5) : 645-56

Evans, J D; Aronstein, K; Chen, Y P; et al.

Nora virus, a persistent virus in Drosophila, defines a new picorna-like virus family.

Journal of General Virology, Vol. 87, (Pt 10) : 3045-3051

Habayeb, Mazen; Ekengren, Sophia; Hultmark, Dan

Insights into social insects from the genome of the honeybee Apis mellifera.

Nature, Vol. 443, (7114) : 931-49

Honeybee Genome Sequencing Consortium, the; Hultmark, Dan

Ultrastructural studies of mutant human transthyretin aggregates in transgenic Drosophila melanogaster

J. Neurogenet., Vol. 20, (3-4) : 203-204

Pokrzywa, Malgorzata; Cantera, Rafael; Dacklin, Ingrid; et al.

View publications in DiVA

Research groups

Head of research

Dan Hultmark Lab

Research projects

9 March 2007 until 31 December 2008

The immune response in Drosophila